24124-59-2

Basic information

• Product Name: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene
• Synonyms: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene;METHYLENE BIS(TOLUENE-4-SULFONATE);Methylene Bis-tosylate;methylene ditosylate
• CAS NO: 24124-59-2
• Molecular Formula: C₁₅H₁₆O₆S₂
• Molecular Weight: 356.42
• Mol File: 24124-59-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 116-118°C
• Boiling Point: 523.2°Cat760mmHg
• Flash Point: 270.2°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 1.61E-10mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene(24124-59-2)
• EPA Substance Registry System: 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene(24124-59-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 24124-59-2(Hazardous Substances Data)

Usage

General Description

1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene is a highly complex and long-named chemical compound with a molecular formula of C18H20O6S2. It is a sulfone derivative that contains two sulfonyl groups, as well as a benzene ring with multiple substituents. 1-methyl-4-[(4-methylphenyl)sulfonyloxymethoxysulfonyl]benzene is likely to be involved in pharmaceutical or industrial applications due to its intricate structure and potential reactivity. However, further information about its specific uses, properties, and potential hazards would be necessary to fully understand its significance in chemistry and industry.

InChI:InChI=1/C15H16O6S2/c1-12-3-7-14(8-4-12)22(16,17)20-11-21-23(18,19)15-9-5-13(2)6-10-15/h3-10H,11H2,1-2H3

Upstream product

• 16836-95-6 silver(I) 4-methylbenzenesulfonate 
• 74-95-3 1,1-dibromomethane 
• 74-88-4 methyl iodide 
• 593-71-5 Chloroiodomethane 
• 80-48-8 methyl p-toluene sulfonate 
• 75-11-6 diiodomethane 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 835605-47-5 [18F]FCH 
• 1638151-15-1 C₂₈H₂₅N₅O₅S 
• 455-16-3 p-toluenesulfonyl fluoride 
• 114435-86-8 fluoromethyl 4-methylbenzenesulfonate 
• 1596347-54-4 di-tert-butyl (p-toluenesulfonylmethyl) phosphate 
• 113426-16-7 [18F]fluoromethylene toluene-4-sulfonate 
• 121424-77-9 7,11,15,28-tetrabromo-1,21,23,25-tetrakis(2-phenylethyl)-2,20:3,19-dimetheno-1H,21H,23H,25H-bis[1,3]dioxocino[5,4-i:5',4'-i']benzo[1,2-d:5,4-d']bis[1,3]benzodioxocin 
• 117184-52-8 iodomethyl 4-methylbenzenesulfonate 
• 117184-51-7 bromomethyl 4-toluenesulfonate 
• 117184-50-6 chloromethyl tosylate 
• 91-20-3 naphthalene 
• 24973-91-9 1H-Cyclobutanaphthalene 
• 91894-66-5 4,6-ditosylperhydro-1,4,6-oxadiazonine 

Relevant articles and documents

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol

Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted motifs. One such area is the fluoromethyl group, particularly when required in a fluoroalkylating capacity. The cold fluorination of methylene ditosylate is under evaluated in the literature, often proceeding with low yields or harsh conditions. This report describes a novel microwave method for the rapid nucleophilic fluorination of methylene ditosylate using inexpensive reagents in good isolated yield (65%).

11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography

P-Glycoprotein (P-gp) is an efflux transporter widely expressed at the human blood-brain barrier. It is involved in xenobiotics efflux and in onset and progression of neurodegenerative disorders. For these reasons, there is great interest in the assessmen