24134-25-6 Usage
Aromatic compound
Yes
Aromatic compounds contain a planar, unsaturated ring structure with delocalized electrons, which gives them unique chemical and physical properties.
Benzimidazole ring
Present
The benzimidazole ring is a fused-ring system consisting of a benzene ring and an imidazole ring, which contributes to the compound's aromaticity and reactivity.
Ethanol group
Present
The ethanol group is an organic functional group consisting of an ethyl group (-CH2CH3) attached to a hydroxyl group (-OH), which can participate in various chemical reactions.
Classification
Amino alcohol
Amino alcohols are organic compounds containing both an amine group (-NH2) and an alcohol group (-OH), which can be used as building blocks for the synthesis of various organic compounds.
Industrial and research applications
Yes
The compound has potential uses in various industrial and research applications, including the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.
Potential use as a building block
Yes
Due to its unique structure and functional groups, 1H-Benzimidazole-1-ethanol,2-amino-(9CI) can be used as a starting material for the synthesis of more complex molecules.
Biological activity
Potential
The compound may have biological activity, which could be explored for the development of new drugs or therapeutic agents.
Pharmaceutical sector
Potential applications
The compound's unique structure and functional groups make it a candidate for use in the development of new pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 24134-25-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,3 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 24134-25:
(7*2)+(6*4)+(5*1)+(4*3)+(3*4)+(2*2)+(1*5)=76
76 % 10 = 6
So 24134-25-6 is a valid CAS Registry Number.
24134-25-6Relevant articles and documents
Discovery and development of 2-aminobenzimidazoles as potent antimalarials
Avery, Vicky M.,Challis, Matthew P.,Creek, Darren J.,De Paoli, Amanda,Devine, Shane M.,Kigotho, Jomo K.,MacRaild, Christopher A.,Norton, Raymond S.,Scammells, Peter J.,Siddiqui, Ghizal
, (2021/06/03)
The emergence of Plasmodium falciparum resistance to frontline antimalarials, including artemisinin combination therapies, highlights the need for new molecules that act via novel mechanisms of action. Herein, we report the design, synthesis and antimalarial activity of a series of 2-aminobenzimidazoles, featuring a phenol moiety that is crucial to the pharmacophore. Two potent molecules exhibited IC50 values against P. falciparum 3D7 strain of 42 ± 4 (3c) and 43 ± 2 nM (3g), and high potency against strains resistant to chloroquine (Dd2), artemisinin (Cam3.IIC580Y) and PfATP4 inhibitors (SJ557733), while demonstrating no cytotoxicity against human cells (HEK293, IC50 > 50 μM). The most potent molecule, possessing a 4,5-dimethyl substituted phenol (3r) displayed an IC50 value of 6.4 ± 0.5 nM against P. falciparum 3D7, representing a 12-fold increase in activity from the parent molecule. The 2-aminobenzimidazoles containing a N1-substituted phenol represent a new class of molecules that have high potency in vitro against P. falciparum malaria and low cytotoxicity. They possessed attractive pharmaceutical properties, including low molecular weight, high ligand efficiency, high solubility, synthetic tractability and low in vitro clearance in human liver microsomes.
