243982-82-3

Basic information

• Product Name: 2,2',4,5'-TETRABROMODIPHENYL ETHER
• Synonyms: 2,2',4,5'-TETRABROMODIPHENYL ETHER;BDE-49;2,2μ,4,5μ-TetraBDE, 2,2μ,4,5μ-Tetrabromodiphenyl ether solution, PBDE 49;BDE No 49 solution;(2,4-Dibromophenyl)(2,5-dibromophenyl) ether;2,4-Dibromophenyl 2,5-dibromophenyl ether;2,2′,4,5′-TetraBDE;1,4-Dibromo-2-(2,4-dibromophenoxy)benzene
• CAS NO: 243982-82-3
• Molecular Formula: C12H6Br4O
• Molecular Weight: 485.79144
• EINECS: 208-759-1
• Mol File: 243982-82-3.mol
• Article Data: 2

Chemical Properties

• Flash Point: -12 °C
• Appearance: /
• Density: 2.161±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2',4,5'-TETRABROMODIPHENYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2',4,5'-TETRABROMODIPHENYL ETHER(243982-82-3)
• EPA Substance Registry System: 2,2',4,5'-TETRABROMODIPHENYL ETHER(243982-82-3)

Safety Data

• Hazard Codes: F,Xn,N
• Statements: 11-38-50/53-65-67
• Safety Statements: 60-61-62-33-29-16-9
• RIDADR: UN 1262 3/PG 2
• WGK Germany: 2
• Hazardous Substances Data: 243982-82-3(Hazardous Substances Data)

Usage

Description

2,2',4,5'-TETRABROMODIPHENYL ETHER, also known as PBDE 49, is a polybrominated diphenyl ether (PBDE) that belongs to a class of flame retardant chemicals. It is characterized by its ability to inhibit combustion and reduce the risk of fire in various materials. Due to its chemical structure, it has been widely used in the industry for its flame-retardant properties.

Uses

Used in Polymer Industry:
2,2',4,5'-TETRABROMODIPHENYL ETHER is used as an additive for [improving fire safety and reducing flammability] in a variety of polymers, such as plastics, textiles, and electronics. The application reason is its effectiveness in slowing down the spread of fire and reducing the heat release rate, thus providing an additional layer of protection against火灾 (fire) and potential damage.
However,

Upstream product

• 28165-52-8 2,5-dibromophenol 
• 3638-73-1 2,5-dibromoaniline 

Relevant articles and documents

Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway

Polybrominated diphenyl ethers (PBDEs) have become widely distributed as environmental contaminants due to their use as flame retardants. Their structural similarity to other halogenated aromatic pollutants has led to speculation that they might share toxicological properties such as hepatic enzyme induction. In this work we synthesized a number of PBDE congeners, studied their affinity for rat hepatic Ah receptor through competitive binding assays, and determined their ability to induce hepatic cytochrome P-450 enzymes by means of EROD (ethoxyre-sorufin-O-deethylase) assays in human, rat, chick, and rainbow trout cells. Both pure PBDE congeners and commercial PBDE mixtures had Ah receptor binding affinities 10-2-10-5 times that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In contrast with polychlorinated biphenyls, Ah receptor binding affinities of PBDEs could not be related to the planarity of the molecule, possibly because the large size of the bromine atoms expands the Ah receptor's binding site. EROD activities of the PBDE congeners followed a similar rank order in all cells. Some congeners, notably PBDE 85, did not follow the usual trend in which strength of Ah receptor binding affinity paralleled P-450 induction potency. Use of the gel retardation assay with a synthetic oligonucleotide indicated that in these cases the liganded Ah receptor failed to bind to the DNA recognition sequence.