244047-66-3

Basic information

• Product Name: N-(2-carboxybenzoyl)-L-leucine methyl ester
• Synonyms: N-(2-carboxybenzoyl)-L-leucine methyl ester
• CAS NO: 244047-66-3
• Molecular Weight: 293.32
• Mol File: 244047-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-carboxybenzoyl)-L-leucine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-carboxybenzoyl)-L-leucine methyl ester(244047-66-3)
• EPA Substance Registry System: N-(2-carboxybenzoyl)-L-leucine methyl ester(244047-66-3)

Safety Data

• Hazardous Substances Data: 244047-66-3(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 85-44-9 phthalic anhydride 
• 7517-19-3 methyl (L)-leucinate hydrochloride 

Downstream Products

• 6707-69-3 N-(o-carboxybenzoyl)-L-leucine 

Relevant articles and documents

Reactions of N-(o-carboxybenzoyl)-L-leucine: Intramolecular catalysis of amide hydrolysis and imide formation by two carboxy groups

The intramolecular reactions of N-(o-carboxybenzoyl)-L-leucine (1) were studied in aqueous solution, as a function of the hydrogen ion concentration. Two competing reactions were observed: i) cyclization to form the imide N-phthaloylleucine, and ii) hydrolysis of (1) to phthalic acid and leucine. Individual rate constants for cyclization and hydrolysis were obtained from the overall rate constants and product distributions. Imide formation predominates under highly acidic conditions (H0 0 > -1 to pH 5 range. In the hydrolysis reaction, the neighbouring carboxy group participates nucleophilically and in the pH 3-5 range there is a requirement for participation of the second carboxy group as a general acid. Imide formation also requires participation of two carboxy groups in the pH 2-5 range, and shows a bell-shaped pH-rate constant profile. Possible mechanisms for these reactions are discussed.