2444-36-2 Usage
Description
2-Chlorophenylacetic acid, a derivative of acetic acid with a chlorophenyl group attached, is a white to light yellow powder. It possesses an acidity constant (pKa) that has been evaluated in water, indicating its potential reactivity and properties in various chemical reactions.
Uses
Used in Pharmaceutical Industry:
2-Chlorophenylacetic acid is used as a synthetic intermediate for the production of various pharmaceutical compounds, particularly those with phenylacetoxy cellulosics and their halogenated derivatives. Its unique chemical structure allows for the creation of a wide range of medications with diverse therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Chlorophenylacetic acid serves as a key building block for the development of various organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex molecules for research and industrial applications.
Used in Research and Development:
2-Chlorophenylacetic acid is also utilized in research and development settings, where its chemical properties and reactivity are studied to understand its potential applications in various scientific fields. This includes the exploration of its use in the creation of new materials, pharmaceuticals, and other innovative products.
Check Digit Verification of cas no
The CAS Registry Mumber 2444-36-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,4 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2444-36:
(6*2)+(5*4)+(4*4)+(3*4)+(2*3)+(1*6)=72
72 % 10 = 2
So 2444-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H7ClO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)/p-1
2444-36-2Relevant articles and documents
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Smith,Fahey
, p. 3391,3392 (1959)
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Method for converting benzyl borate compounds into phenylacetic acid and derivatives thereof by carbon dioxide
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Paragraph 0038-0039, (2020/03/06)
The invention discloses a method for converting benzyl borate compounds into phenylacetic acid and derivatives thereof by carbon dioxide. The method comprises the steps: dissolving the benzyl borate compounds and an alkali in an organic solvent in the absence of a metal catalyst, introducing carbon dioxide into the reaction system, carrying out a reaction at the temperature of 50-150 DEG C for 3-72 hours, and acidifying to obtain phenylacetic acid or the derivatives thereof. The method is a green, simple and efficient method for synthesizing phenylacetic acid and the derivatives thereof, greenhouse gas carbon dioxide is used as a carbon source in the reaction, no transition metal catalyst is used, and the method is environmentally friendly, economical and high in efficiency.
Electrogenerated Sm(II)-Catalyzed CO2 Activation for Carboxylation of Benzyl Halides
Bazzi, Sakna,Schulz, Emmanuelle,Mellah, Mohamed
supporting information, p. 10033 - 10037 (2019/12/24)
Sm(II)-catalyzed carboxylation of benzyl halides is reported through the electrochemical reduction of CO2. The transformation proceeds under mild reaction conditions to afford the corresponding phenylacetic acids in good to excellent yields. This user-friendly and operationally simple protocol represents an alternative to traditional strategies, which usually proceeds through the C(sp3)-halide activation pathway.