24573-34-0

Basic information

• Product Name: N-heptylpyridin-2-amine
• CAS NO: 24573-34-0
• Molecular Formula: C₁₂H₂₀N₂
• Molecular Weight: 192.3006
• Mol File: 24573-34-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 304.1°C at 760 mmHg
• Flash Point: 137.7°C
• Density: 0.955g/cm³
• Vapor Pressure: 0.00089mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: N-heptylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-heptylpyridin-2-amine(24573-34-0)
• EPA Substance Registry System: N-heptylpyridin-2-amine(24573-34-0)

Safety Data

• Hazardous Substances Data: 24573-34-0(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 111-68-2 1-Heptylamine 
• 109-04-6 2-bromo-pyridine 
• 504-29-0 2-aminopyridine 
• 111-70-6 n-heptan1ol 

Downstream Products

• 893429-21-5 3-{3-[2-(heptyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid ethyl ester 
• 850724-10-6 3-{4-[2-(heptyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid methyl ester 

Relevant articles and documents

Palladium(II) acetate as catalyst for the N-alkylation of aromatic amines, sulfonamides, and related nitrogenated compounds with alcohols by a hydrogen autotransfer process

Palladium(II) acetate is a versatile, inexpensive, and simple catalyst for the selective N-monoalkylation of amino derivatives with poor nucleophilic character, such as aromatic and heteroaromatic amines as well as carboxamides, sulfonamides, and phosphazenes, using, in all cases, primary alcohols as the initial source of the electrophile, through a hydrogen autotransfer process. The regioselectivity of the benzothiazol-2-amine alkylation is contrary to that found using halogenated electrophiles.

Identification of novel PPARα ligands by the structural modification of a PPARγ ligand

To develop novel PPARα ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives. Compound 10, the meta isomer of a PPARγ agonist 1, has been identified as a PPARα ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARα-binding potency.