246525-75-7

Basic information

• Product Name: 3-(4-Methoxyphenyl)-5-methoxy-3H-isobenzofuran-1-one
• Synonyms: 3-(4-Methoxyphenyl)-5-methoxy-3H-isobenzofuran-1-one
• CAS NO: 246525-75-7
• Molecular Weight: 270.285
• Mol File: 246525-75-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(4-Methoxyphenyl)-5-methoxy-3H-isobenzofuran-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methoxyphenyl)-5-methoxy-3H-isobenzofuran-1-one(246525-75-7)
• EPA Substance Registry System: 3-(4-Methoxyphenyl)-5-methoxy-3H-isobenzofuran-1-one(246525-75-7)

Safety Data

• Hazardous Substances Data: 246525-75-7(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 7465-88-5 4-methoxy-N-phenylbenzamide 
• 1272675-92-9 5-methoxy-3-(4-methoxyphenyl)-3H-isobenzofuran-1-ylidenamine 
• 100-07-2 4-methoxy-benzoyl chloride 

Relevant articles and documents

Application of organolithium and related reagents in synthesis, Part 24.1 Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzoic acids into 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids

The synthesis of the 3-arylphthalides 3 via metallation (BuLi) of the benzanilides 1 and subsequent reaction of the generated bis-lithiated anilides 2 with aromatic aldehydes is described. Conversion of 3 into the corresponding 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids 4 by treatment with 1-methoxy-1-trimethylosiloxyethene in the presence of titanium tetrachloride, as a way of regiospecific transformation of benzoic acids, is also described.

Conversion of 3-arylphthalides into anthrones with a methylcarbonyl substituent at the C-10 position

The ortho-lithiation of a benzoic acid anilide followed by condensation with an aryl aldehyde gave a 3-arylphthalide. Reductive alkylation with 1-methoxy-1-trimethylsilyloxyethene gave a substituted aromatic carboxylic acid which was cyclised to an anthro