247-92-7

Basic information

• Product Name: 1,2,4-Triazolo[3,4-b]benzothiazole
• Synonyms: 1,2,4-Triazolo[3,4-b]benzothiazole;7-thia-2,4,5-triazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,5,9,11-pentaene;1,2,4-triazolobenzothiazole
• CAS NO: 247-92-7
• Molecular Formula: C8H5N3S
• Molecular Weight: 175
• Mol File: 247-92-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 175-176 °C
• Appearance: /
• Density: 1.58g/cm³
• Refractive Index: 1.857
• PKA: 2.11±0.30(Predicted)
• CAS DataBase Reference: 1,2,4-Triazolo[3,4-b]benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[3,4-b]benzothiazole(247-92-7)
• EPA Substance Registry System: 1,2,4-Triazolo[3,4-b]benzothiazole(247-92-7)

Safety Data

• Hazardous Substances Data: 247-92-7(Hazardous Substances Data)

Usage

General Description

1,2,4-Triazolo[3,4-b]benzothiazole is a heterocyclic compound that consists of a triazole ring fused with a benzothiazole ring. It has potential applications in medicinal chemistry, specifically as a scaffold for drug development. The compound has been investigated for its antibacterial, antifungal, and anti-inflammatory properties. 1,2,4-Triazolo[3,4-b]benzothiazole has also been studied for its potential as an anticancer agent and has shown promising activity against various cancer cell lines. Its unique chemical structure and biological activities make it an interesting target for further research in the development of new medicinal compounds.

InChI:InChI=1/C8H5N3S/c1-2-4-7-6(3-1)11-5-9-10-8(11)12-7/h1-5H

Upstream product

• 615-21-4 1,3-benzothiazol-2-ylhydrazine 
• 64-18-6 formic acid 
• 2740-81-0 2-chlorophenylisothiocyanate 
• 624-84-0 formic acid hydrazide 
• 122-51-0 orthoformic acid triethyl ester 
• 1404101-25-2 4-[2-(4-methoxybenzylthio)phenyl]-1,2,4-4H-triazole 
• 82725-45-9 2-(4-methoxy-phenylmethylthio)-aniline 
• 137-07-5 2-amino-benzenethiol 
• 116577-86-7 3,4-dihydro-2H-as-triazino<3,4-b>benzothiazole-3,4-dione 
• 180967-55-9 3-chloro-1,2,4-triazolo[3,4-b]benzothiazol-4(H)-one 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 3028-06-6 2-Acetylaminobenzothiazole 

Relevant articles and documents

Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via C-H Bond Functionalization of Disulfide Intermediates

Many nitrogen-and sulfur-containing heterocyclic compounds exhibit biological activity. Among these heterocycles are benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles for which two main synthetic approaches exist. Here we report a new synthetic protocol that allows the preparation of these tricyclic compounds via the oxidation of a mercaptophenyl moiety to its corresponding disulfide. Subsequent C-H bond functionalization is thought to enable an intramolecular ring closure, thus forming the desired benzo[4,5]thiazolo[2,3-c][1,2,4]triazole. This method combines a high functional group tolerance with short reaction times and good to excellent yields.

Synthesis and reactions of substituted 2H-as-triazino[3,4-b]benzothiazole-3,4-diones

3,4-Dihydro-2H-as-triazino[3,4-b]benzothiazole-3,4-diones (1a-c) have been synthesized by condensing substituted 2-hydrazinobenzothiazoles with diethyl oxalate. Three Mannich bases (2a-c) and N-phenacyl derivative (3) have been prepared from parent lactam

Agent for the control of plant-pathogenic organisms

Methods employing and compositions comprising, for the control of plant-pathogenic organisms, specified triazolobenzoxazole and triazolobenzothiazole compounds; and novel methods for the preparation of the compounds.