248243-49-4

Basic information

• Product Name: Fmoc-Pro-Thr(Ψ^Me,Mepro)-OH
• CAS NO: 248243-49-4
• Molecular Weight: 478.545
• Mol File: 248243-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc-Pro-Thr(Ψ^Me,Mepro)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Pro-Thr(Ψ^Me,Mepro)-OH(248243-49-4)
• EPA Substance Registry System: Fmoc-Pro-Thr(Ψ^Me,Mepro)-OH(248243-49-4)

Safety Data

• Hazardous Substances Data: 248243-49-4(Hazardous Substances Data)

Upstream product

• 125281-38-1 Fmoc-L-proline pentafluorophenyl ester 
• 71989-31-6 Fmoc-Pro-OH 
• 77-76-9 2,2-dimethoxy-propane 
• 144575-17-7 Fmoc-Pro-Thr-OH 

Relevant articles and documents

Pseudo-prolines in cyclic peptides: Conformational stabilisation of cyclo[Pro-Thr(Ψ(Me,Me)pro)-Pro]

Linear peptide H-Pro-Thr(Ψ(Me,Me)pro)-Pro-OH containing a preformed cis-Pro-Thr(Ψ(Me,Me)pro) tertiary amide bond cyclises instantaneously and free of formation of oligomeric structures to the cyclic tripeptide cyclo- [Pro-Thr(Ψ(Me,Me)pro)-Pro]. Even at concentrations up to 10-1 M peptide, no oligomeric structures are detected by mass spectroscopy and HPLC. 2D 1H NMR studies of purified cyclotripeptide reveal the compound to exist in one single conformation with all peptide bonds in the cis conformation. These results indicate enhanced cyclisation tendencies of cis-amide bond containing peptides of short chain length.