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2483-62-7

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2483-62-7 Usage

Description

2-aminobutyric acid methyl ester, also known as β-amino-n-butyric acid methyl ester, is a white solid chemical compound belonging to the class of organic compounds known as alpha amino acid esters. It is derived from the amino acid GABA (gamma-aminobutyric acid) and has a molecular weight of 133.17 g/mol. The methyl ester group in this compound allows it to be easily incorporated into a variety of chemical reactions, making it a versatile and valuable chemical in the field of organic chemistry.

Uses

Used in Pharmaceutical Industry:
2-aminobutyric acid methyl ester is used as a reagent in organic synthesis for the production of pharmaceuticals. Its versatile chemical properties enable it to be incorporated into various chemical reactions, aiding in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
2-aminobutyric acid methyl ester is used as a building block in the synthesis of various organic compounds, including agrochemicals. Its ability to participate in a range of chemical reactions contributes to the creation of new agrochemical products for agricultural applications.
Used in Organic Synthesis:
2-aminobutyric acid methyl ester is used as a versatile building block in the synthesis of various organic compounds. Its methyl ester group allows for easy incorporation into a wide array of chemical reactions, making it a valuable component in the development of new organic compounds for various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 2483-62-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 2483-62:
(6*2)+(5*4)+(4*8)+(3*3)+(2*6)+(1*2)=87
87 % 10 = 7
So 2483-62-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NO2/c1-3-4(6)5(7)8-2/h4H,3,6H2,1-2H3

2483-62-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 2-aminobutanoate

1.2 Other means of identification

Product number -
Other names Methyl 2-aminobutyrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2483-62-7 SDS

2483-62-7Relevant articles and documents

Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors

Lei, Meng,Zhang, Haoyang,Miao, Hang,Du, Xiao,Zhou, Hui,Wang, Jia,Wang, Xueyuan,Feng, Huayun,Shi, Jingmiao,Liu, Zhaogang,Shen, Jian,Zhu, Yongqiang

, p. 4151 - 4162 (2019/08/07)

A series of novel tetrapeptidyl epoxyketone inhibitors of 20S proteasome was designed and synthesized. To fully understand the SAR, various groups at R1, R2, R3, R4 and R5 positions, including aromatic and aliphatic substituents were designed, synthesized and biologically assayed. Based on the enzymatic results, seven compounds were selected to evaluate their cellular activities and soluble compound 36 showed strong potency against human multiple myeloma (MM) cell lines. Microsomal stability results indicated that compound 36 was more stable in mice, rat and human microsomes than marketed carfilzomib. The in vivo activities of this compound were evaluated with the xenograft mice models of MM cell lines ARH77 and RPMI-8226 with luciferase expression and the T/C value of the two models were 49.5% and 37.6%, respectively. To evaluate the potential cardiovascular toxicity, inhibition of hERG ion channel in HEK293 cells by compound 36 and carfilzomib was carried out. The results indicated that 36 had no binding affinity for the hERG ion channel while carfilzomib could bind it with IC50 of 92.1 μM.

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors

Liu, Shuai,Yosief, Hailemichael O.,Dai, Lingling,Huang, He,Dhawan, Gagan,Zhang, Xiaofeng,Muthengi, Alex M.,Roberts, Justin,Buckley, Dennis L.,Perry, Jennifer A.,Wu, Lei,Bradner, James E.,Qi, Jun,Zhang, Wei

, p. 7785 - 7795 (2018/09/13)

The simultaneous inhibition of polo-like kinase 1 (PLK1) and BRD4 bromodomain by a single molecule could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and BRD4 are implicated. Compound 23 has been found to be a potent dual kinase-bromodomain inhibitor (BRD4-BD1 IC50 = 28 nM, PLK1 IC50 = 40 nM). Compound 6 was found to be the most selective PLK1 inhibitor over BRD4 in our series (BRD4-BD1 IC50 = 2579 nM, PLK1 IC50 = 9.9 nM). Molecular docking studies with 23 and BRD4-BD1/PLK1 as well as with 6 corroborate the biochemical assay results.

DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

-

Page/Page column 78, (2012/08/08)

Dihydroperidinone derivatives, preparation process and pharmaceutical use thereof are disclosed. Specially, new dihydroperidinone derivatives represented by general formula (I), wherein each substituent of the general formula (I) is defined as in the description, their preparation process, pharmaceutical compositions comprising said derivatives and their use as therapeutical agents, especially as Plk kinase inhibitors are disclosed.

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