25173-76-6

Basic information

• Product Name: 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-(3,4-diMethylphenyl)propanoic acid;Benzenepropanoic acid, 3,4-diMethyl-;3-(3,4-Dimethylphenyl);3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID;3,4-DiMethylbenzenepropanoic acid
• CAS NO: 25173-76-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• Mol File: 25173-76-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 80-82℃
• Boiling Point: 311.4°C at 760 mmHg
• Flash Point: 208.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0.000241mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID(25173-76-6)
• EPA Substance Registry System: 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID(25173-76-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 25173-76-6(Hazardous Substances Data)

Usage

Description

3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID, also known as 3-(3,4-Dimethylphenyl)propionic acid, is an organic compound with the chemical formula C11H14O2. It is a derivative of propionic acid, featuring a 3,4-dimethylphenyl group attached to the third carbon. 3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID is characterized by its potential applications in various industries, particularly in the pharmaceutical sector.

Uses

Used in Pharmaceutical Industry:
3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID is used as a reagent for the preparation of pyrazolotetrahydropyridines, which are known as orexin receptor antagonists. These antagonists play a crucial role in the development of medications targeting various conditions, such as insomnia, addiction, and other disorders related to the central nervous system. The compound's unique structure allows it to interact with specific receptors, modulating their activity and providing therapeutic benefits.

InChI:InChI=1/C11H14O2/c1-8-3-4-10(7-9(8)2)5-6-11(12)13/h3-4,7H,5-6H2,1-2H3,(H,12,13)

Upstream product

• 5779-93-1 2,3-dimethylbenzaldehyde 
• 79-10-7 acrylic acid 
• 7440-32-6 titanium 
• 60521-25-7 3,4-dimethylcinnamic acid 
• 102-46-5 4-(chloromethyl)-1,2-dimethylbenzene 
• 105-53-3 diethyl malonate 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 619-04-5 3,4-dimethylbenzoic acid 
• 38404-42-1 methyl 3,4-dimethylbenzoate 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 147219-20-3 3-(3,4-Dimethylphenyl)-propensaeure 

Downstream Products

• 16440-97-4 5,6-Dimethylindan-1-one 
• 16440-98-5 6,7-dimethyl-2,3-dihydro-1H-inden-1-one 
• 112631-49-9 3-(2-bromo-4,5-dimethylphenyl)propionic acid 
• 26801-37-6 3-(3,4-dimethylphenyl)propionyl chloride 
• 142332-70-5 3-(3,4-dimethylphenyl)propylamine 
• 1075-22-5 5,6-dimethylindane 

Relevant articles and documents

Aldehyde as a Traceless Directing Group for Regioselective C-H Alkylation Catalyzed by Rhodium(III) in Air

The aromatic aldehyde as a traceless directing group for the regionselective C-H alkylation catalyzed by rhodium(III) under aerobic atmospheric conditions has been developed. The process involves an aldehyde assisted direct addition of C-H bond to unsaturated electrophiles of acrylates or acrylic acids, and the subsequent decarbonylation. A trace amount of water is found to favor the reaction.

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

N-Arylalkylphenylacetamide derivatives

N-arylalkylphenylacetamide compounds of formula (I), and pharmaceutically acceptable salts thereof, possess potent analgesic and anti-inflammatory activities. STR1