25191-13-3

Basic information

• Product Name: POLY-L-PROLINE
• Synonyms: POLY-L-PROLINE;polyproline;poly-L-proline mol wt 10000-30000;poly-L-proline mol wt 1000-10000;poly-L-proline mol wt greater than*30000;Poly(Pro)
• CAS NO: 25191-13-3
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.13046
• Product Categories: Amino Acids;Homopolymers;Polyamino Acids
• Mol File: 25191-13-3.mol
• Article Data: 337

Chemical Properties

• Boiling Point: 252.2°Cat760mmHg
• Flash Point: 106.3°C
• Appearance: /
• Density: 1.186g/cm³
• Storage Temp.: −20°C
• CAS DataBase Reference: POLY-L-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: POLY-L-PROLINE(25191-13-3)
• EPA Substance Registry System: POLY-L-PROLINE(25191-13-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 25191-13-3(Hazardous Substances Data)

Usage

General Description

Poly-L-proline is a synthetic polymer composed of repeated units of the amino acid proline. It is commonly used in biochemistry and biotechnology for a variety of applications, including as a model system for studying protein folding and stability, as a component in drug delivery systems, and as a scaffold for tissue engineering. Poly-L-proline has a unique helical structure that mimics the conformation of proline-rich regions in proteins, making it an important tool for studying protein-protein interactions and designing peptide-based drugs. Its biocompatibility and biodegradability also make it a promising material for biomedical applications, such as in the development of implants and tissue regeneration therapies.

InChI:InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)

Upstream product

• 21761-19-3 (+/-)-5-amino-2-chloro-valeric acid 
• 1450-81-3 2,5-dibromopentanoic acid 
• 6326-44-9 diethyl 2-formylaminomalonate 
• 109-70-6 1.3-chlorobromopropane 
• 109-64-8 1,3-dibromo-propane 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 123-75-1 pyrrolidine 
• 64-18-6 formic acid 
• 141-53-7 sodium formate 
• 79068-39-6 Natrium-(3-chlor-1-pyrrolin-2-carboxylat) 
• 147-85-3 L-proline 
• 75-05-8 acetonitrile 
• 1148-11-4 N-carbobenzyloxyproline 
• 103238-71-7 N-(3,5-dinitrobenzoyl)-L-proline 

Downstream Products

• 119910-72-4 1,2,3,3aα,4β,6,7,8,8aα,8bα-decahydro-2-phenyl-4-(2-pyridyl)pyrrolo<3,4-a>pyrrolizine-1,3-dione 
• 119910-72-4 1,2,3,3aα,4α,6,7,8,8aβ,8bα-decahydro-2-phenyl-4-(2-pyridyl)pyrrolo<3,4-a>pyrrolizine-1,3-dione 
• 107326-39-6 1-But-3-enyl-pyrrolidine-2-carboxylic acid 
• 18877-34-4 1,2,3,11a-tetrahydro-10H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11-dione 
• 7364-47-8 TMS-DL-Pro-OTMS 
• 137441-49-7 C₂₅H₃₄N₂O₃ 
• 73004-43-0 N-Carbethoxy-prolin 
• 108286-48-2 3-Methyl-1-phenyl-6,7-dihydro-5H-pyrrolizine-2-carbonitrile 
• 108286-45-9 3-Methyl-2-phenyl-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid methyl ester 
• 108286-44-8 3-Methyl-1-phenyl-6,7-dihydro-5H-pyrrolizine-2-carboxylic acid methyl ester 
• 1074-79-9 N-Acetyl-DL-prolin 
• 103847-61-6 (2R,3S,7aR)-2,3-Bis-(4-nitro-phenyl)-hexahydro-pyrrolo[2,1-b]oxazole 
• 103847-61-6 (2S,3S,7aR)-2,3-Bis-(4-nitro-phenyl)-hexahydro-pyrrolo[2,1-b]oxazole 
• 80514-78-9 Trit-Pro-OH.Et2NH 

Relevant articles and documents

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Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

COMPOSITIONS AND METHODS FOR USING FIXED BIOLOGICAL SAMPLES IN PARTITION-BASED ASSAYS

The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.