2530-26-9 Usage
Description
3-Nitropyridine is a chemical compound belonging to the class of nitro heterocycles, characterized by the presence of a nitro group (-NO2) attached to a pyridine ring. It is an important intermediate in the synthesis of various organic compounds and pharmaceuticals due to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
3-Nitropyridine is used as a key intermediate in the synthesis of biologically active nitro heterocyclic compounds, which have potential applications as pharmaceutical agents. These compounds can exhibit a range of therapeutic properties, such as antimicrobial, anti-inflammatory, and anticancer activities.
Used in Organic Synthesis:
3-Nitropyridine serves as a versatile building block in organic synthesis, allowing for the preparation of a variety of complex organic molecules. Its reactivity can be exploited to form new chemical bonds and functional groups, making it a valuable component in the development of novel chemical entities and materials.
Synthesis
In 1993 Suzuki and co-workers reported the nitration of pyridine with nitrogen dioxide and ozone in dichloromethane at room temperature. They obtained a 3.5 % yield of 3-nitropyridine and 1.2 % of 3,5-dinitropyridine. 3-Nitropyridines can also be synthesized by oxidation of 3-aminopyridine with hydrogen peroxide in fuming sulphuric acid in 45% yield. Nitration of 2,6-dichloropyridine with nitronium tetrafluoroborate gave a 11% yield of 3-nitropyridine after dehalogenation. 3-nitropyridine has also been prepared from 2- chloro-3-nitropyridine.
Check Digit Verification of cas no
The CAS Registry Mumber 2530-26-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,3 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2530-26:
(6*2)+(5*5)+(4*3)+(3*0)+(2*2)+(1*6)=59
59 % 10 = 9
So 2530-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H4N2O2/c8-7(9)5-2-1-3-6-4-5/h1-4H
2530-26-9Relevant articles and documents
Efficient synthesis of nebularine and vidarabine via dehydrazination of (hetero)aromatics catalyzed by CuSO4 in water
Xia, Ran,Xie, Ming-Sheng,Niu, Hong-Ying,Qu, Gui-Rong,Guo, Hai-Ming
, p. 1077 - 1081 (2014/03/21)
A simple dehydrazination reaction has been achieved in the presence of a catalytic amount of CuSO4 for the first time. With CuSO4 (2 mol%) as a catalyst and water as a solvent, the dehydrazination products were obtained in good yields (66-95%). Moreover, the drugs nebularine and vidarabine were afforded successfully, and vidarabine could be produced on a 0.923 kg scale, which shows good potential for industrial applications.
Reductive cleavage of heteroaryl C-halogen bonds by iodotrimethylsilane. Facile and regioselective dechlorination of antibiotic pyrrolnitrin
Sako,Kihara,Okada,Ohtani,Kawamoto
, p. 3610 - 3612 (2007/10/03)
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