25372-14-9

Basic information

• Product Name: 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL
• Synonyms: 2H-Imidazole-2-thione,1,3-dihydro-1-(2-methylphenyl)-
• CAS NO: 25372-14-9
• Molecular Formula: C₁₀H₁₀N₂S
• Molecular Weight: 190.27
• Mol File: 25372-14-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 289.5°Cat760mmHg
• Flash Point: 128.9°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.0022mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL(25372-14-9)
• EPA Substance Registry System: 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL(25372-14-9)

Safety Data

• Hazardous Substances Data: 25372-14-9(Hazardous Substances Data)

Usage

Description

1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL, with the molecular formula C10H9NS, is a heterocyclic chemical compound that features both sulfur and nitrogen atoms in its structure. This versatile compound has garnered interest in the fields of medicinal chemistry and pharmaceutical development due to its potential applications and biological activity.

Uses

Used in Pharmaceutical Synthesis:
1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is used as a chelating ligand in the pharmaceutical industry for its ability to form stable complexes with metal ions, which can be crucial in the development of new drugs with enhanced properties and targeted action.
Used in Agrochemical Development:
In the agrochemical industry, 1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is utilized as a key intermediate in the synthesis of various agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Medicinal Chemistry Research:
1-(2-METHYLPHENYL)-1H-IMIDAZOLE-2-THIOL is employed as a subject of interest in medicinal chemistry research due to its potential biological activity. Its unique structure allows for exploration in the development of novel therapeutic agents and understanding its interactions with biological targets.

InChI:InChI=1/C10H10N2S/c1-8-4-2-3-5-9(8)12-7-6-11-10(12)13/h2-7H,1H3,(H,11,13)

Upstream product

• 3129-90-6 isothiocyanic acid 
• 60185-84-4 3-aminopropionaldehyde dimethyl acetal 
• 614-69-7 2-tolyl isothiocyanate 

Downstream Products

• 161190-54-1 3-(1-o-tolyl-1H-imidazol-2-ylsulfanyl)propan-1-ol 
• 161190-39-2 (+/-)-3,4-dihydro-6-<3-(1-o-tolyl-2-imidazolyl)sulfinylpropoxy>-2(1H)-quinolinone 
• 161190-55-2 (S)-3-(1-o-tolyl-1H-imidazol-2-ylsulfanyl)propan-1-ol 
• 173416-61-0 (R)-(+)-3,4-dihydro-6-<2-hydroxy-3-(1-o-tolyl-2-imidazolyl)thiopropoxy>-2(1H)-quinolinone 
• 116072-39-0 2-methylthio-1-o-tolyl-1H-imidazole 
• 113857-31-1 3,4-dihydro-6-<3-(1-o-tolyl-2-imidazolyl)thiopropoxy>-2(1H)-quinolinone 

Relevant articles and documents

New bis(mercaptoimidazolyl)(pyrazolyl)borate ligands and their zinc complex chemistry

Nine new tripodal NS2 ligands of the bis(mercaptoimidazolyl)(pyrazolyl)borate type with varying 3-R-mercaptoimidazolyl moieties were prepared as their potassium salts. Treatment with zinc salts yielded the complex types L·Zn-Cl, L·Zn-I, L·Zn-ONO2, L·Zn-OClO3 and [L·Zn(imidazole)]ClO4. Attempts at the formation of L·Zn-OH or cationic L·Zn complexes resulted in dismutation and formation of ZnL2 complexes. Hydrolytic destruction yielded one [OZn4(thiooimidazolate)6] complex. The ZnS2NO coordination which is present in the enzyme-substrate complex of alcohol dehydrogenase could be successfully modelled by an [L·Zn(C2H5OH)]+ complex. The L·Zn-X complexes showed very low catalytic activity in the dehydrogenation of 2-propanol or the hydrogenation of p-nitrobenzaldehyde. The new compounds were identified by a total of 12 structure determinations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.