25407-30-1Relevant articles and documents
Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
Venugopala, Katharigatta N.,Chandrashekharappa, Sandeep,Deb, Pran Kishore,Tratrat, Christophe,Pillay, Melendhran,Chopra, Deepak,Al-Shar’i, Nizar A.,Hourani, Wafa,Dahabiyeh, Lina A.,Borah, Pobitra,Nagdeve, Rahul D.,Nayak, Susanta K.,Padmashali, Basavaraj,Morsy, Mohamed A.,Aldhubiab, Bandar E.,Attimarad, Mahesh,Nair, Anroop B.,Sreeharsha, Nagaraja,Haroun, Michelyne,Shashikanth, Sheena,Mohanlall, Viresh,Mailavaram, Raghuprasad
, p. 1472 - 1487 (2021/07/10)
A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in?vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a
Ultrasound-promoted regioselective synthesis of chalcogeno-indolizines by a stepwise 1,3-dipolar cycloaddition
Vieira, Marcelo M.,Dalberto, Bianca T.,Coelho, Felipe L.,Schneider, Paulo H.
, (2020/07/03)
A series of new organochalcogen derivatives of indolizines was synthesized in moderate to excellent yields from pyridinium salts and chalcogeno-alkynes. The reaction can be carried out under thermal conditions or by sonochemical processes in short reaction times. The stepwise cycloaddition reaction forming chalcogeno-indolizines is regioselective and extends to a broad range of functional groups. Furthermore, novel chalcogeno-alkynes are reported and the first derivatives of teluro-indolizine are described. The influence of selenium functionalization on the photophysical properties of indolizines is also described, in which the compounds showed absorption in the UV–Vis region around 360 nm and emission in the blue-to-green region. Relatively low fluorescence quantum yield (?fl) values were calculated, in agreement with the chalcogen effect on other heterocycles.
DMAP-Catalyzed Annulation Approach for Modular Assembly of Furan-Fused Chromenes
He, Xinwei,Li, Ruxue,Choy, Pui Ying,Liu, Tianyi,Wang, Junya,Yuen, On Ying,Leung, Man Pan,Shang, Yongjia,Kwong, Fuk Yee
supporting information, p. 9444 - 9449 (2020/12/21)
With a tandem DMAP-catalyzed reaction between o-AQM, in which it is generated in situ from propargylic amine, and acyl carbene surrogate (from pyridinium ylide), a variety of polyarylated chromenes are assembled in good yields. This process does not require transition-metal catalyst and exhibits easy manipulation of the arene group and good functional group compatibility, particularly the -Br group which can be further transformed to other functionalities by cross-coupling reactions. The modular feature of o-AQM substrates and the simple operation procedures add further advantages to this synthetic method.
