25458-44-0Relevant articles and documents
First total synthesis of mariamide A
Xia, Yamu,Chen, Chenglong,Li, Mengying,Zhou, Weizeng,Sun, Shuyu,Chu, Shanpeng,Wang, Hui
, p. 114 - 120 (2020)
Mariamide A, a lignanamide isolated from the seeds of Silybum marianum, has demonstrated potential utility as an antioxidant and antidiabetic agent and possesses an 8-O-4′ neolignan skeleton. Herein, a first total synthesis of mariamide A is presented that proceeds in nine steps using vanillin as the starting material. The key steps for the preparation of mariamide A involve an I2-catalyzed bromomethoxylation of an alkene group, a nucleophilic substitution followed by a sequential elimination and a monoacylation reaction.
Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells
Bielsa, Núria,Casasampere, Mireia,Aseeri, Mazen,Casas, Josefina,Delgado, Antonio,Abad, José Luis,Fabriàs, Gemma
, (2021/03/08)
Acid (AC), neutral (NC) and alkaline ceramidase 3 (ACER3) are the most ubiquitous ceramidases and their therapeutic interest as targets in cancer diseases has been well sustained. This supports the importance of discovering potent and specific inhibitors
COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
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Paragraph 00576, (2020/06/10)
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.