2557-77-9Relevant articles and documents
A general and efficient approach to aryl thiols: Cul-catalyzed coupling of aryl iodides with sulfur and subsequent reduction
Jiang, Yongwen,Qin, Yuxia,Xie, Siwei,Zhang, Xiaojing,Dong, Jinhua,Ma, Dawei
supporting information; scheme or table, p. 5250 - 5253 (2009/12/28)
A Cul-catalyzed coupling reaction of aryl iodides and sulfur powder takes place in the presence of K2CO3 at 90 °C. The coupling mixture is directly treated with NaBH4 or triphenylphosphine to afford aryl thiols in good to
Oxidative Cleavage of S-Arylmercaptoacetic Acids by Sodium Perborate: Kinetic and Correlation Study
Kabilan, S.,Pandiarajan, K.,Krishnasamy, K.,Sankar, P.
, p. 443 - 452 (2007/10/02)
Kinetics of oxidation of twenty six S-arylmercaptoacetic acids (SAMA) (I) by sodium perborate (PB) have been studied in acid medium.The product of oxidation is the corresponding thiophenol.The rate data of meta- and para-substituted acids have been correlated with DSP equations.While the para-compounds correlate well with ?I and ?0R values, the meta-compounds correlate well with ?I and ?-R values.The reaction constants are negative and of smaller magnitudes.Further, the ortho-substituted acids show a good correlation with a triparametric equation involving Taft's ?I and ?0R and Charton's steric parameter ν.There is a considerable steric contribution to the total ortho-substituent effect.Based on these observations, mechanism involving the formation of protonated arylsulfinylacetic acid intermediate, followed by an intramolecular rearrangement leading to the product thiophenol has been proposed.
NONCATALEPTIC NEUROLEPTIC AGENTS: 4-SUBSTITUTED 1-(2-CHLORO-7-FLUORO-10,11-DIHYDRODIBENZOTHIEPIN-10-YL)PIPERAZINES AND RELATED COMPOUNDS
Protiva, Miroslav,Jilek, Jiri,Cervena, Irena,Pomykacek, Josef,Bartl, Vaclav,et al.
, p. 2598 - 2616 (2007/10/02)
1-(2-chloro-7-fluoro-10,11-dihydrodibenzothiepin-10-yl)piperazine (VI) was used to prepare a new group of potential noncataleptic neuroleptic agents.Addition of acrylonitrile and acrylamide gave the nitrile VII and the amide X.Further transformations of the nitrile VII led to the phenone VIII and the amidoxime IX.Alkylations of compound VI with 2-(2-chloroethyl)-1,3-dioxolane and 2-(2-chloroethyl)-1,3-dioxane resulted in the cyclic acetals XII and XIII.Several improvements of the synthesis of compound VI are reported.Out of the compounds prepared, the amide X (methanesulfonate VUFB-15496) proved most interesting: it has low acu te toxicity, is noncataleptic and has significantly higher antidopaminergic activity than clozapine.
