25602-39-5

Basic information

• Product Name: N-Thiazol-2-yl-forMaMide
• Synonyms: N-Thiazol-2-yl-forMaMide
• CAS NO: 25602-39-5
• Molecular Formula: C₄H₄N₂OS
• Molecular Weight: 128.15236
• Mol File: 25602-39-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 156-161 °C(Solv: benzene (71-43-2))
• Boiling Point: 240.1±23.0 °C(Predicted)
• Appearance: /
• Density: 1.441±0.06 g/cm3(Predicted)
• PKA: 8.70±0.70(Predicted)
• CAS DataBase Reference: N-Thiazol-2-yl-forMaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Thiazol-2-yl-forMaMide(25602-39-5)
• EPA Substance Registry System: N-Thiazol-2-yl-forMaMide(25602-39-5)

Safety Data

• Hazardous Substances Data: 25602-39-5(Hazardous Substances Data)

Upstream product

• 96-50-4 2-thiazolylamine 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 64-18-6 formic acid 
• 6142-05-8 aminothiazole hydrochloric acid 
• 592-84-7 n-butyl formate 
• 255842-15-0 2-Thiazolyl isocyanide 
• 67-66-3 chloroform 
• 68970-85-4 thiazolo[3,2-a]pyrimidinylium; chloride 
• 17720-99-9 4-aminothiazole 
• 1558-67-4 formic anhydride 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 6142-06-9 2-methylaminothiazole 
• 18876-89-6 N¹,N¹-dimethyl-N²-(thiazol-2-yl)formamidine 
• 53995-64-5 3-amino-2-formylamino-thiazolium; 2,4,6-trimethyl-benzenesulfonate 

Relevant articles and documents

Covalently bonded zwitterionic sulfamic acid onto the SBA-15 (SBA-15/PrEn-NHSO3H) reveals good Bronsted acidity behavior and catalytic activity in N-formylation of amines

Ethylenediamine-functionalization of SBA-15 with N1-(3-(trimethoxysilyl)propyl)ethane-1,2-diamine (PrEn) was then underwent covalent sulfonation over secondary and primary amine groups (SBA-15/PrEn-NHSO3H) on the surface of the mesoporous SBA-15 pore walls. Scanning electron microscope (SEM), transmission electron microscope (TEM), SEM-energy dispersive X-ray (SEM-EDX), BET surface are analysis, thermal gravimetric (TG), FT-IR spectrums and CHNS were recorded for the characterization of SBA-15/PrEn-NHSO3H. This material was studied as a novel catalyst for N-formylation of amines. Based on the results, SBA-15/PrEn-NHSO3H acted as zwitterionic IL-type heterogeneous catalyst with simple separation feature from the reaction mixture. Moreover, it exhibited excellent recyclability at least for 12 times, and a higher catalytic activity toward N-formylation.

Preparation and catalytically study of metal-organic frameworks of amine/MIL-53 (Al) as a powerful option in the rapid N-formylation condensation in neat conditions

This paper reports on the preparation and application of amine/MIL-53 (Al) as highly active catalysts for the N-formylation reaction. These Al-MOFs were found to be an efficient, selective and waste-free green solid catalyst for the net condensation of amines and formic acid. The catalyst can be isolated from the reaction mixture and reused at least 6 times.

Synthesis and rearrangement of N-methyl-N-(2-thiazolyl)-nitramine

Methylation of N-(2-thiazolyl)-nitramine in alkaline solution gives 1,2-dihydro-3-methyl-2-nitriminothiazole which rearranges in concentrated sulphuric acid yielding small amount of 2-(N-methylamino)-5-nitrothiazole, identical with the product of rearrangement of N-methyl-N-(2-thiazolyl)-nitramine. The latter compound was obtained by the action of sodium hydride on 2-(N-methylamino)-thiazole followed by the nitration with n-butyl nitrate.