257880-47-0

Basic information

• Product Name: 2-phenyl-4-[(1-methylindol-3-yl)methylene]-1,3-oxazol-5(4H)-one
• CAS NO: 257880-47-0
• Molecular Weight: 302.332
• Mol File: 257880-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-[(1-methylindol-3-yl)methylene]-1,3-oxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-[(1-methylindol-3-yl)methylene]-1,3-oxazol-5(4H)-one(257880-47-0)
• EPA Substance Registry System: 2-phenyl-4-[(1-methylindol-3-yl)methylene]-1,3-oxazol-5(4H)-one(257880-47-0)

Safety Data

• Hazardous Substances Data: 257880-47-0(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 19012-03-4 N-methyl-3-formylindole 

Downstream Products

• 257880-58-3 N-[1-(N-glycine ethyl ester)-1-oxo-3-(1-methylindol-3-yl)prop-2-en-2-yl]benzamide 

Relevant articles and documents

Aminolysis and Hydrolysis of Indolyl Oxazolones

The aminolysis of 2-methyl (or phenyl)-4-[(sub-indol-3-yl)methylene]-1,3-oxazol-5(4H)-one with morpholine, N-methylpiperazine [dry dioxane at 0-10 deg C] and with substituted amino acid esters [dry tetrahydrofuran at 0-10 deg C] afforded N-[1-(subamino acid ester)-1-oxo-3-(sub-indol-3-yl)-prop-2-en-2-yl]acetamides (or benzamides). The hydrolysis of 2-phenyl-4-[(1-acetyl-6-nitroindol-3-yl)methylene]-1,3-oxazol-5(4H)-one with aqueous hydrochloric acid gave the corresponding α-hydroxy acid, which condensed with hydroxylamine hydrochloride to give the corresponding oxime which was reduced with zinc in glacial acetic acid to furnish a new amino acid ester.