259217-95-3

Basic information

• Product Name: Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-
• Synonyms: Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-;(1R,2S)-ethyl 1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate;Ethyl (1R,2S)-1-[(tert-butoxycarbonyl)amino]-2-ethenylcyclopropanecarboxylate;(1S,2S)-ethyl 1-(tert-butoxycarbonylaMino)-2-vinylcyclopropanecarboxylate;(1R,2S)-Boc-amino-2-vinylcyclopropane ethyl ester
• CAS NO: 259217-95-3
• Molecular Formula: C₁₃H₂₁NO₄
• Molecular Weight: 255.31
• Mol File: 259217-95-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 328℃
• Appearance: /
• Density: 1.084
• Storage Temp.: 2-8°C
• PKA: 10.60±0.40(Predicted)
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-(259217-95-3)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-(259217-95-3)

Safety Data

• Hazardous Substances Data: 259217-95-3(Hazardous Substances Data)

Usage

Description

Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)is a complex organic compound with a unique cyclopropane ring structure. It features an ethyl ester group and an amino group attached to a carbonyl group, which is connected to a dimethylethoxy group. Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)is characterized by its stereochemistry, with the (1R,2S) configuration, indicating the specific arrangement of atoms in its three-dimensional structure.

Uses

Used in Pharmaceutical Industry:
Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)is used as an intermediate in the biosynthetic preparation of several hepatitis C inhibitors. Its unique structure and functional groups make it a valuable building block for the development of antiviral drugs targeting the hepatitis C virus.
In the pharmaceutical industry, this compound plays a crucial role in the synthesis of drugs that can effectively combat hepatitis C, a viral infection that affects the liver and can lead to severe health complications if left untreated. Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-'s specific stereochemistry and functional groups enable the design of inhibitors that can target and disrupt the life cycle of the hepatitis C virus, thereby helping to control the infection and alleviate symptoms in affected individuals.

InChI:O=C(OCC)[C@]1(NC(=O)OC(C)(C)C)[C@H](\C=C)C1

Upstream product

• 787548-29-2 (1R,2S)/(1S,2R) 1-amino-2-vinylcyclopropane carboxylic acid ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1393095-18-5 (E)-ethyl 1-(benzylideneamino)-2-vinylcyclopropanecarboxylate 
• 213316-32-6 rac-(1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 1023795-84-7 C₂₁H₂₁NO₂ 
• 681807-59-0 (1R,2S)-ethyl 1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate 
• 681807-60-3 (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride 
• 1159609-95-6 (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester tosylate salt 
• 213316-49-5 (1RS,2SR)-ethyl 2-vinyl-1-(tert-butoxycarbonylamino)cyclopropanecarboxylate 
• 259214-54-5 (trans)-ethyl 1-amino-2-vinylcyclopropanecarboxylate hydrochloride 

Downstream Products

• 746657-36-3 (1R,2S)-ethyl 1-amino-2-vinylcyclopropanecarboxylate 
• 259214-54-5 ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride 
• 259214-54-5 ethyl (1S,2R)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride 
• 630421-48-6 tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate 
• 1279037-85-2 (1R,2R)-1-(tert-butoxycarbonylamino)-2-vinyl-cyclopropane-1-carboxylic acid 
• 1195976-54-5 C₄₄H₄₇F₃N₆O₉S 
• 862119-82-2 (2S,4R)-tert-butyl 2-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)-4-hydroxypyrrolidine-1-carboxylate 
• 862119-83-3 (1R,2S)-1-[(2S,4R)-(4-hydroxy-pyrrolidine-2-carbonyl)-amino]-2-vinyl-cyclopropanecarboxylic acid ethyl ester 
• 552335-44-1 (1R,2S)-ethyl 1-((2S,4R)-1-((S)-2-(((tert-butoxy)carbonyl)amino)non-8-enoyl)-4-hydroxypyrrolidine-2-carboxamido)-2-vinylcyclopropanecarboxylate 
• 213316-49-5 (1RS,2SR)-ethyl 2-vinyl-1-(tert-butoxycarbonylamino)cyclopropanecarboxylate 
• 213316-49-5 (1RS,2SR)-ethyl 2-vinyl-1-(tert-butoxycarbonylamino)cyclopropanecarboxylate 
• 923591-34-8 tert-butyl ((1R,2R)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-ethylcyclopropyl)carbamate 
• 853269-57-5 tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate 
• 1152134-45-6 (1R,2R)-1-(tert-butoxycarbonylamino)-2-(difluoromethyl)cyclopropanecarboxylic acid 

Relevant articles and documents

CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF

The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.

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MACROCYCLIC PEPTIDES AS HEPATITIS C VIRUS INHIBITORS

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