25932-48-3

Basic information

• Product Name: 2-Quinolinamine, N-methyl-N-phenyl-
• CAS NO: 25932-48-3
• Molecular Formula: C16H14N2
• Molecular Weight: 234.301
• Mol File: 25932-48-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Quinolinamine, N-methyl-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Quinolinamine, N-methyl-N-phenyl-(25932-48-3)
• EPA Substance Registry System: 2-Quinolinamine, N-methyl-N-phenyl-(25932-48-3)

Safety Data

• Hazardous Substances Data: 25932-48-3(Hazardous Substances Data)

Usage

General Description

2-Quinolinamine, N-methyl-N-phenyl-, also known as Methanamine, N-methyl-N-phenyl-, is a chemical compound that consists of a quinoline ring with a methyl group and a phenyl group attached to the nitrogen atom. It is a white crystalline solid with a molecular formula of C15H14N2. 2-Quinolinamine, N-methyl-N-phenyl- is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. Additionally, 2-Quinolinamine, N-methyl-N-phenyl-, has been studied for its potential anti-cancer properties and has shown promising results in inhibiting the growth of certain cancer cells. However, further research is needed to fully understand its potential uses and effects.

Upstream product

• 1436-43-7 quinoline-2-carbonitrile 
• 100-61-8 N-methylaniline 
• 6931-16-4 2-methoxy-quinoline 
• 101444-29-5 N-methyl-N-phenyl-2-quinolinecarboxamide 
• 1613-37-2 Quinoline N-oxide 
• 93-61-8 N-methyl-N-phenylformamide 
• 612-62-4 2-Chloroquinoline 

Relevant articles and documents

Heteroarylation method of amine

The invention discloses a heteroarylation method of amine, and the method comprises the following steps of: mixing an amine compound, heteroaromatic hydrocarbon, a photocatalyst and an organic solventto obtain a solution A; and in an inert gas atmosphere, irradiating the solution A with visible light, and carrying out reaction to obtain a heteroarylated product of amine. According to the method,under mild conditions, free radical coupling of amine compounds and heteroaromatic compounds is efficiently achieved through visible light irradiation, and various heteroarylamines are synthesized. The method has good functional group compatibility and high regioselectivity, can be further applied to later modification of bioactive molecules, and shows a good industrial application prospect.

Metal-free, redox-neutral, site-selective access to heteroarylamine via direct radical?radical cross-coupling powered by visible light photocatalysis

Transition-metal-catalyzed C?N bond-forming reactions have emerged as fundamental and powerful tools to construct arylamines, a common structure found in drug agents, natural products, and fine chemicals. Reported herein is an alternative access to heteroarylamine via radical?radical cross-coupling pathway, powered by visible light catalysis without any aid of external oxidant and reductant. Only by visible light irradiation of a photocatalyst, such as a metal-free photocatalyst, does the cascade single-electron transfer event for amines and heteroaryl nitriles occur, demonstrated by steady-state and transient spectroscopic studies, resulting in an amine radical cation and aryl radical anion in situ for C?N bond formation. The metal-free and redox economic nature, high efficiency, and site-selectivity of C?N cross-coupling of a range of available amines, hydroxylamines, and hydrazines with heteroaryl nitriles make this protocol promising in both academic and industrial settings.

Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.