2601-89-0

Basic information

• Product Name: 2,3-Dichloropropionitrile
• Synonyms: DCPN;A B-DICHLOROPROPIONITRILE;2,3-DICHLOROPROPIONITRILE;2,3-Dichloropropanenitrile;Propanenitrile, 2,3-dichloro-;2,3-dichloropropiononitrile;2,3-DICHLORO-2-PROPANENITRILE;DICHLOROPROPIONITRILE
• CAS NO: 2601-89-0
• Molecular Formula: C₃H₃Cl₂N
• Molecular Weight: 123.97
• EINECS: 220-007-4
• Mol File: 2601-89-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 243 °C (decomp)
• Boiling Point: 62-63°C 13mm
• Flash Point: 62-63°C/13mm
• Appearance: /
• Density: 1,35 g/cm3
• Vapor Pressure: 0.484mmHg at 25°C
• Refractive Index: 1.4640 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-Dichloropropionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloropropionitrile(2601-89-0)
• EPA Substance Registry System: 2,3-Dichloropropionitrile(2601-89-0)

Safety Data

• Statements: 23/24/25
• Safety Statements: 23-36/37/39-45
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 2601-89-0(Hazardous Substances Data)

Usage

Description

2,3-Dichloropropionitrile, also known as 2,3-dichloropropenenitrile, is an organic compound with the chemical formula C3H2Cl2N. It is a colorless to pale yellow liquid with a pungent odor. 2,3-Dichloropropionitrile is a valuable intermediate in the synthesis of various organic compounds and has potential applications in different industries.

Uses

Used in Chemical Synthesis:
2,3-Dichloropropionitrile is used as a reagent in the preparation of functionalized 3-aminothiphenes. It serves as a key intermediate in the synthesis of these heterocyclic compounds, which have potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-dichloropropionitrile is used as a building block for the synthesis of various drug molecules. Its unique structure allows for the formation of diverse chemical entities with potential therapeutic properties.
Used in Agrochemical Industry:
2,3-Dichloropropionitrile is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its reactivity and functional group compatibility make it a suitable candidate for the development of new and effective agrochemical products.
Used in Materials Science:
In the field of materials science, 2,3-dichloropropionitrile can be used as a precursor for the synthesis of novel polymers and materials with specific properties. Its ability to form various chemical bonds and its compatibility with different monomers make it a valuable component in the development of advanced materials.

InChI:InChI=1/C3H3Cl2N/c4-1-3(5)2-6/h3H,1H2/t3-/m0/s1

Upstream product

• 107-13-1 acrylonitrile 
• 75-09-2 dichloromethane 
• 749251-98-7 azidoacetylene 
• 60-29-7 diethyl ether 
• 813-74-1 2,2,3-trichloropropionitrile 

Downstream Products

• 565-64-0 2,3-dichloropropanoic acid 
• 122454-23-3 2-(p-chlorophenyl)-5-(trifluoromethyl)-pyrrole-3-carbonitrile 
• 4284-52-0 3-(4-acetamidobenzenesulfonyl) acrylonitrile 
• 77433-13-7 3-Amino-2-chlor-propionitril 
• 920-37-6 2-Chloroacrylonitrile 
• 598-79-8 2-Chloroacrylic acid 
• 1128-56-9 3-amino-1-phenylpyrazole 
• 40165-01-3 2,3-Dichloro-N-{[(2-chloro-acetyl)-(2,6-diethyl-phenyl)-amino]-methyl}-propionamide 
• 19433-84-2 α,β-dichloropropionamide 
• 1750-42-1 3-aminoisoxazole 

Relevant articles and documents

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Synthesis method of DL-cysteine

The invention discloses a synthetic method of DLcysteine. The method comprises the following steps: by using acrylonitrile as a raw material, chlorinating to generate 2, 3dichloropropionitrile, hydrolyzing to generate corresponding acid, reacting the acid with thiourea to cyclize to generate 2-aminothiazoline-4-carboxylic acid, adding alkali sulfide to generate 2-mercaptothiazoline-4-carboxylic acid, and hydrolyzing to generate cysteine. The synthesis method provided by the invention has the advantages of short synthesis steps, mild preparation conditions, sufficient and cheap raw material sources and higher product yield.

The photochemical and thermal decomposition of azidoacetylene in the gas phase, solid matrix, and solutions

Decomposition of the extremely explosive and unstable parent compound of 1-azidoalkynes, HCCN3 (azidoacetylene), was studied in the gas phase, solid argon matrix, and solutions. In the gas phase, this azide decomposes quickly at room temperature with a half-life time (t1/2) of 20 min at an initial pressure (p0) of 0.8 mbar. The decay (p0 = 1.0 mbar) is significantly increased in an atmosphere of O2 with t 1/2 of 3 min, in which HC(O)CN was identified as the trapping product of the cyanocarbene intermediate HCCN. Trapping products of this carbene by solvent molecules (CH2Cl2 and CHCl3) were also found during decomposition of the azide in solution, whereas the reaction with a solution of bromine to form dibromoacetonitrile is interpreted as taking place by nucleophilic attack of the alkyne itself. The intermediary formation of triplet HCCN by flash vacuum pyrolysis and photolysis (255 nm) of the azide in the gas phase and in solid argon matrices, respectively, was confirmed by IR spectroscopy and mutual photo-interconversion of HCCN with isomeric cyclo-C(H)CN (azirinylidene) and HCNC by selective irradiations at 16 K. Although azidoacetylene is highly explosive, it can be irradiated in an argon matrix to generate cyanocarbene. The same species is also formed and analyzed after flash vacuum pyrolysis under relatively mild conditions. Decomposition of the azide in solution is combined with trapping reactions. Copyright

Process for the production of 2,3-dichloropropionitrile

In a process for the production of 2,3-dichloropropionitrile by the chlorination of acrylonitrile, the improvement which comprises chlorinating acrylonitrile in the presence of pyridine or an alkylpyridine in combination with an alkaline earth metal carbonate.