2602-88-2Relevant articles and documents
Effect of anions on cadmium(II) complexes with ligand 2-(pyrazin-2-yl)-1H- benzimidazole
Wang, Yong-Tao,Yan, Shi-Chen,Tang, Gui-Mei,Zhao, Chao,Li, Tian-Duo,Cui, Yue-Zhi
, p. 492 - 499 (2011)
Three new supramolecular complexes based on a 2-(pyrazin-2-yl)-1H- benzimidazole (Hpbi) and a series of Cd(II) salts have been solvothermally synthesized and structurally characterized by single-crystal X-ray diffraction analysis. Reaction of CdCl2·2.5H2O with Hpbi afforded a one-dimensional chain [Cd(Hpbi)Cl2] (1), which exhibits a three-dimensional (3-D) supramolecular architecture through intermolecular X-H?Cl (X = N and C) hydrogen bonds and π-π stacking interactions. When using CdBr2·4H2O instead of CdCl 2·2.5H2O under similar reaction conditions, a bisnuclear complex [Cd(Hpbi)2Br2] (2) is obtained, which obviously exhibits intermolecular X-H?Br (X = N and C) hydrogen bonds and π-π stacking interactions. When CdI2 take place of CdCl 2·2.5H2O, a mononuclear complex, [Cd(Hpbi) 2I2] (3), is isolated, which shows a 3D supramolecule framework formed by intermolecule hydrogen bonds and π-π packing interactions. Interestingly, the Hpbi ligand exhibits the same coordination modes in complexes 1-3. It is noteworthy that the radius of anions plays an important role in affecting the structures and luminescent intensity of the final products. The TGA for 1-3 have been investigated and discussed in detail.
Synthesis and spectroscopic properties of 2,5-bis(benzoazol-2-yl)pyrazines
Saito, Ryota,Machida, Shinnosuke,Suzuki, Saori,Katoh, Akira
, p. 531 - 536 (2008)
A class of π-conjugated 2,5-bis(benzoazol-2-yl)pyrazine dyes have been synthesized in which 2,5-bis(benzimidazol-2-yl)pyrazine (1) exhibits strong fluorescence in solution. The enhanced fluorescence of 1 with a base leads to future applications such as anion sensing feasible upon chemical modification.
Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions
Schiffmann, Rolf,Neugebauer, Alexander,Klein, Christian D.
, p. 511 - 522 (2007/10/03)
We report the discovery of thiabendazole as a potent inhibitor (K 1 = 0.4 μM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range, Elucidation of the X-ray structure of ecMetAP in complex with thiabendazole and an unrelated inhibitor that was independently described by another group showed that that both compounds bind to an additional CoII ion at the entrance of the active site. This unexpected finding explains the inactivity of the compounds under in vivo conditions. It also allows us to discuss the structure-activity relationships of this series of compounds in a meaningful way, based upon docking runs with an auxiliary metal ion, We describe a new scoring function for the evaluation of metal-mediated inhibitor binding that, unlike the previously used scoring function implemented in the docking program, allows us to distinguish between active and inactive compounds, Finally, conclusions for the structure-based design of in vivo-active inhibitors of ecMetAP are drawn.
