26124-78-7 Usage
Description
POLY-L-LYSINE HYDROCHLORIDE is a synthetic polypeptide consisting of L-lysine amino acid residues linked by amide bonds. It is a water-soluble, cationic polymer known for its ability to promote cell adhesion and is widely utilized in various scientific and industrial applications.
Uses
Used in Cell Culture Applications:
POLY-L-LYSINE HYDROCHLORIDE is used as a coating agent for glass slides and coverslips to enhance cell attachment. This application is particularly relevant in the field of cell biology, where it facilitates the growth and maintenance of cells in vitro.
Used in Biomedical Research:
In biomedical research, POLY-L-LYSINE HYDROCHLORIDE is employed as a component in the fabrication of tissue engineering scaffolds and drug delivery systems. Its cationic nature allows for the efficient binding and release of therapeutic agents, making it a valuable tool in the development of novel medical treatments.
Used in Diagnostics:
POLY-L-LYSINE HYDROCHLORIDE is also utilized in the development of diagnostic tools, such as immunoassays and biosensors, due to its ability to bind specifically to target molecules, improving the sensitivity and specificity of these tests.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, POLY-L-LYSINE HYDROCHLORIDE is used as an excipient in the formulation of certain drugs, particularly those that require enhanced stability or controlled release properties. Its cationic nature can also be exploited for the targeted delivery of therapeutic agents to specific cells or tissues.
Used in Genetic Research:
POLY-L-LYSINE HYDROCHLORIDE is employed in genetic research as a transfection agent, facilitating the introduction of nucleic acids into cells for various applications, such as gene expression analysis and functional genomics studies.
Used in Nanotechnology:
In the field of nanotechnology, POLY-L-LYSINE HYDROCHLORIDE is used to create self-assembled structures and nanoparticles for various applications, including drug delivery, imaging, and sensing. Its ability to form stable complexes with a wide range of molecules makes it a versatile building block in the design of nanoscale systems.
Biochem/physiol Actions
L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).
Check Digit Verification of cas no
The CAS Registry Mumber 26124-78-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,1,2 and 4 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 26124-78:
(7*2)+(6*6)+(5*1)+(4*2)+(3*4)+(2*7)+(1*8)=97
97 % 10 = 7
So 26124-78-7 is a valid CAS Registry Number.
26124-78-7Relevant articles and documents
Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids
Octa-Smolin, Frescilia,Thiele, Maike,Yadav, Rohan,Platzek, André,Clever, Guido H.,Niemeyer, Jochen
, p. 6153 - 6156 (2018)
The synthesis and application of three chiral receptors based on the covalent linkage of 1,1′-binaphthylphosphoric acids is reported. The binding of the lysine enantiomers to the chiral receptors was investigated by DOSY-NMR and NMR titrations, revealing that the bisphosphoric acid 1d acts as a highly stereoselective receptor for binding of d-lysine.
Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament
-
, (2008/06/13)
The compounds of the Formula (I) STR1 wherein R1 is a C18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOH X is 0, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is hydrogen metal, and R2 is a side chain of a any amino acid except L-GLU or L-ASP at α-position or a group of Formula wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, A is hydroxyl or one A is hydroxyl and the other A is hydrogen. M is H or R1 --CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.
Sesquiterpene compounds and pharmaceutical compositions containing same, from pachastrella sponges
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, (2008/06/13)
A new class of novel, biologically active sesquiterpene compounds, pharmaceutical compositions containing them, methods of producing the compounds and compositions and methods of using them are disclosed. This new class of compounds have the generic formulae: STR1 and R1, R2, R3, R4, R5, R6, R7 =H or lower alkyl.
