261368-01-8

Basic information

• Product Name: {(R)-2-Phenylmethanesulfonylamino-5-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-acetic acid ethyl ester
• CAS NO: 261368-01-8
• Molecular Weight: 477.541
• Mol File: 261368-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(R)-2-Phenylmethanesulfonylamino-5-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(R)-2-Phenylmethanesulfonylamino-5-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-acetic acid ethyl ester(261368-01-8)
• EPA Substance Registry System: {(R)-2-Phenylmethanesulfonylamino-5-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-acetic acid ethyl ester(261368-01-8)

Safety Data

• Hazardous Substances Data: 261368-01-8(Hazardous Substances Data)

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 98264-52-9 (R)-N^α-Z-N^δ-Boc-ornithine 
• 261367-89-9 (2-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentanoylamino)-acetic acid ethyl ester 
• 261367-95-7 (5-tert-butoxycarbonylamino-2-phenylmethanesulfonylamino-pentanoylamino)-acetic acid ethyl ester 

Relevant articles and documents

Exploratory solid-phase synthesis of factor Xa inhibitors: Discovery and application of P3-heterocyclic amides as novel types of non-basic arginine surrogates

A series of novel FXa inhibitors 2a-m and 3a-f was discovered that feature heterocyclic carboxamides tethered to a d-diaminobutyric acid sidechain. These neutral amide derivatives serve as novel P3 d-arginine mimics. Pyrazine carboxamide scaffolds afforded the most potent FXa inhibitors (e.g., 2b IC50 = 4.6 nM). The synthesis and biological activity of two focused libraries are reported.