263890-17-1

Basic information

• Product Name: 3,4-dimethyl-6-(2,4-difluorophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one
• CAS NO: 263890-17-1
• Molecular Weight: 277.23
• Mol File: 263890-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4-dimethyl-6-(2,4-difluorophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethyl-6-(2,4-difluorophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one(263890-17-1)
• EPA Substance Registry System: 3,4-dimethyl-6-(2,4-difluorophenyl)isoxazolo[3,4-d]pyridazin-7(6H)-one(263890-17-1)

Safety Data

• Hazardous Substances Data: 263890-17-1(Hazardous Substances Data)

Upstream product

• 40594-30-7 2,4-difluorophenylhydrazine 
• 15911-11-2 ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate 

Relevant articles and documents

Isoxazole analogues bind the System xc- transporter: Structure-activity relationship and pharmacophore model

Analogues of amino methylisoxazole propionic acid (AMPA), were prepared from a common intermediate 12, including lipophilic analogues using lateral metalation and electrophilic quenching, and were evaluated at System xc-. Both the 5-naphthylethyl-(16) and 5-naphthylmethoxymethyl-(17) analogues adopt an E-conformation in the solid state, yet while the former has robust binding at System xc-, the latter is virtually devoid of activity. The most potent analogues were amino acid naphthyl-ACPA 7g, and hydrazone carboxylic acid, 11e Y = Y′ = 3,5-(CF3)2, which both inhibited glutamate uptake by the System xc- transporter with comparable potency to the endogenous substrate cystine, whereas in contrast the closed isoxazolo[3,4-d] pyridazinones 13 have significantly lower activity. A preliminary pharmacophore model has been constructed to provide insight into the analogue structure-activity relationships.