267-48-1Relevant articles and documents
Synthesis of 5,6-carbonyldioxyindole, a melanogenic cyclic carbonate ester of 5,6-dihydroxyindole
Lutz,McNamara,Olinger,et al.
, p. 1183 - 1188 (1984)
5,6-Carbonyldioxyindole (4), a melanogenic derivative of 5,6-dihydroxyindole (1), was synthesized by a procedure starting with 3,4-methylenedioxycinnamic acid. Compound 4 is a stable crystalline solid which is readily hydrolyzed to 1, a key intermediate on the biosynthetic pathway from tyrosine to melanin.
INDOLE COMPOUND, OXIDATION DYE INTERMEDIATE, METHOD FOR PRODUCING INDOLE COMPOUND, AND METHOD FOR PRODUCING OXIDATION DYE-CONTAINING SOLUTION
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Paragraph 0080-0081, (2021/09/27)
PROBLEM TO BE SOLVED: To provide a novel indole compound to be a precursor of 5,6-dihydroxy indole, which has the nature of being easily oxidized and is, therefore, limited in its methods for production, a method for producing the indole compound, and a method for producing an oxidation dye-containing solution from the indole compound. SOLUTION: According to a method, a compound of formula (III) and boron trihalide are reacted to synthesize an indole compound, which is a boric acid ester of a 5,6-dihydroxy indole derivative. R1 and R2 independently represent H, a C1-C10 substituted/unsubstituted alkyl group, a C6-C10 substituted/unsubstituted aryl group, an oxygen-containing group, or a halogen atom; R3 is H, or a C1-C10 substituted/unsubstituted alkyl group; R4 and R5 independently represent H or a C1-C12 aliphatic group, or integrally represent a C1-C4 alkylene group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE
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Paragraph 0059, (2019/05/10)
The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl) pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.
SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE
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Paragraph 0122, (2019/02/25)
The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.