26807-69-2

Basic information

• Product Name: SODIUM 1-ACETYLINDOLINE-2-SULFONATE
• Synonyms: SODIUM 1-ACETYLINDOLINE-2-SULFONATE;1-Acetyl-2,3-dihydro-1H-indole-2-sulfonic Acid SodiuM Salt;1-Acetyl indoline-2-sulfonic acid sodium;SODIUM, 1-ACETYL-2,3-DIHYDRO-1H-INDOLE-2-SULFONATE
• CAS NO: 26807-69-2
• Molecular Formula: C₁₀H₁₀NO₄S*Na
• Molecular Weight: 263.25
• Product Categories: Indole Derivatives
• Mol File: 26807-69-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300°C
• Appearance: /
• Solubility: Water
• CAS DataBase Reference: SODIUM 1-ACETYLINDOLINE-2-SULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM 1-ACETYLINDOLINE-2-SULFONATE(26807-69-2)
• EPA Substance Registry System: SODIUM 1-ACETYLINDOLINE-2-SULFONATE(26807-69-2)

Safety Data

• Hazardous Substances Data: 26807-69-2(Hazardous Substances Data)

Usage

Description

SODIUM 1-ACETYLINDOLINE-2-SULFONATE, with the CAS number 26807-69-2, is a white solid compound that is primarily utilized in the field of organic synthesis. It serves as a crucial intermediate in the creation of various organic compounds, contributing to the development of new materials and pharmaceuticals.

Uses

Used in Organic Synthesis:
SODIUM 1-ACETYLINDOLINE-2-SULFONATE is used as a synthetic intermediate for the production of various organic compounds. Its unique chemical structure allows it to be a versatile building block in the synthesis of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, SODIUM 1-ACETYLINDOLINE-2-SULFONATE is used as a key component in the development of new drugs. Its incorporation into drug molecules can enhance their efficacy, selectivity, and pharmacokinetic properties, leading to improved therapeutic outcomes for patients.
Used in Agrochemical Industry:
SODIUM 1-ACETYLINDOLINE-2-SULFONATE also finds application in the agrochemical industry, where it is used to synthesize novel compounds with potential pesticidal, herbicidal, or fungicidal properties. These new compounds can help address the challenges of pest resistance and crop protection, contributing to increased agricultural productivity and food security.
Used in Specialty Chemicals:
In the specialty chemicals sector, SODIUM 1-ACETYLINDOLINE-2-SULFONATE is employed in the synthesis of various high-value compounds with specific applications. These can include dyes, pigments, additives, and other performance-enhancing chemicals that are used across different industries, such as plastics, textiles, and coatings.

Upstream product

• 26807-68-1 indolin-2-sulfonic acid sodium 
• 108-24-7 acetic anhydride 
• 120-72-9 indole 

Downstream Products

• 10075-50-0 5-bromo-1H-indole 
• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 
• 121103-34-2 1-benzyl-5-bromo-1H-indole-3-carboxaldehyde 

Relevant articles and documents

A 5 - cyano indole synthesis method (by machine translation)

The invention relates to a 5 - cyano indole synthesis method, through to indole as the starting material, with sodium bisulfite reaction, and then sequentially by acetylation, brominated, protection, [...] and de-protected to obtain 5 - cyano indole. The present invention provides a method of synthesis of the price of raw materials is low cost and easily, thereby reducing the production cost. At the same time the invention synthetic route is short, high yield, high chemical purity of the obtained product, all the reactions are not need special production equipment, and the produced intermediate and final products are not needs the column chromatography and crystallization purification. So the invention not only reduces production cost, convenient for the industrial scale production; and can provide the market with high purity products, obtain the good economic benefits. (by machine translation)

Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives

This work presents the first structure-based activity prediction model for benzothiadiazines against various genotypes of HCV NS5b polymerase (1a, 1b and 4).The model is a comprehensive workflow of structure-based field template followed by guided docking. The field template was used as a pre-filter and a tool to provide hits in good orientation and position. It was created based on detailed molecular interaction field analysis which includes Topomer CoMFA, grid independent analysis and Superstar. On the other hand, Guided docking was used as a refinement and assessment tool. It was actively directed by two scores: Moldock score as an interaction descriptor (r2 = 0.65) and a template similarity score as a measure for accurate binding-mode compliance. The docking template was based on energy-based pharmacophore analysis. The whole procedure was formulated and tweaked for both screening (ROC of AUC = 0.91) and activity prediction (r2 of 0.8) for the genotype 1a. In order to widen the model scope, linear interaction energy was used as a tool for predicting activities of other genotypes based on the docked ligand poses while mutation binding energy was used to investigate the effect of each amino acid mutation in genotype 4. The model was applied for structure-based fragment hopping by screening a library designed by reaction enumeration. A top scoring hit was used to generate a focused library such that it has lower TPSA than the original class ligands and thus better pharmacokinetic properties. After that, experimental validation was carried out by the synthesis of this library and its biological evaluation which yielded compounds that exhibit EC50 ranging from 1.86 to 23 μM.