268741-98-6Relevant articles and documents
tert-buyldiphenylsilylethyl ("TBDPSE"): A practical protecting group for phenols
Gerstenberger, Brian S.,Konopelski, Joseph P.
, p. 1467 - 1470 (2005)
(Chemical Equation Presented) A new protection group for phenols, the 2-(tert-butyldiphenylsilyl)ethyl (TBDPSE) group, has been prepared and investigated. Protection of a variety of substituted phenols proceeds in good to excellent yield. The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/ halogen exchange on the protected phenol. Removal is achieved with strong acid or standard fluoride treatment.
Synthesis of a cyclic pentapeptide mimic of the active site His-Tyr cofactor of cytochrome c oxidase
Mahoney, Maximillian E.,Oliver, Allen,Einarsdottir, Oloef,Konopelski, Joseph P.
supporting information; experimental part, p. 8212 - 8218 (2010/02/17)
(Chemical Equation Presented) Arylboronic acid based technology provides a mild, regioselective, and nontoxic N-arylation procedure for accessing the unusual N-arylated side chain histidine found in the active site of cytochrome c oxidase (CcO). The N-ary
Inhibitors of protein tyrosine phosphatase
-
, (2008/06/13)
The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).