27347-14-4

Basic information

• Product Name: 4-(4-METHOXY-PHENYL)-MORPHOLINE
• Synonyms: 4-(4-METHOXY-PHENYL)-MORPHOLINE;4-(Morpholino)anisole;N-(4-Methoxyphenyl)morpholine;NSC 686502
• CAS NO: 27347-14-4
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Product Categories: pharmacetical
• Mol File: 27347-14-4.mol
• Article Data: 244

Chemical Properties

• Melting Point: 79℃
• Boiling Point: 335.7°Cat760mmHg
• Flash Point: 141.6°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.92±0.40(Predicted)
• CAS DataBase Reference: 4-(4-METHOXY-PHENYL)-MORPHOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXY-PHENYL)-MORPHOLINE(27347-14-4)
• EPA Substance Registry System: 4-(4-METHOXY-PHENYL)-MORPHOLINE(27347-14-4)

Safety Data

• Hazardous Substances Data: 27347-14-4(Hazardous Substances Data)

Usage

General Description

4-(4-Methoxy-Phenyl)-Morpholine, often abbreviated as 4-MPM, belongs to the category of organic compounds known as tetracyclic compounds. This chemical is particularly significant in the world of synthetic organic chemistry. It is characterized by a morpholine ring, which is a six-membered ring containing four carbon atoms, one oxygen atom, and one nitrogen atom, attached to a 4-methoxyphenyl moiety. This unique structure renders it vital in a variety of applications, such as serving as building blocks for complex compound synthesis and as a precursor material in pharmaceutical manufacturing, among other uses. Specific information about its toxicity, safety issues, and physical and chemical properties may need to be sourced from comprehensive chemical databases or material safety data sheet.

InChI:InChI=1/C11H15NO2/c1-13-11-4-2-10(3-5-11)12-6-8-14-9-7-12/h2-5H,6-9H2,1H3

Upstream product

• 104-94-9 4-methoxy-aniline 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 111-46-6 diethylene glycol 
• 110-91-8 morpholine 
• 696-62-8 para-iodoanisole 
• 623-12-1 4-chloromethoxybenzene 
• 1448-52-8 N,N-bis(2-chloroethyl)-4-methoxybenzenamine 
• 140-29-4 phenylacetonitrile 
• 108-88-3 toluene 
• 5982-21-8 1-N-morpholino-4-methoxy-1-cyclohexene 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 7460-82-4 diethylene glycol ditosylate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 5765-65-1 4-(benzoyloxy)morpholine 

Downstream Products

• 1227403-26-0 3-allyl-4-(4-methoxyphenyl)morpholine 
• 1415461-04-9 1-(5-methoxy-2-morpholinophenyl)naphthalen-2-ol 
• 568577-88-8 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine 
• 1351403-44-5 4-(4-deuteriophenyl)morpholine 
• 92-53-5 4-Phenylmorpholine 
• 383870-96-0 4-(4-methoxy-3-nitrophenyl)morpholine 
• 31543-39-2 4-(4-methoxy-cyclohexa-1,3-dienyl)-morpholine 
• 152999-90-1 (5-{[5-(Hydroxy-phenyl-methyl)-1H-pyrrol-2-yl]-p-tolyl-methyl}-1H-pyrrol-2-yl)-(4-methoxy-phenyl)-methanol 
• 152999-89-8 1-p-Anisoyl-9-benzoyl-5-p-tolyldipyrromethane 
• 152999-88-7 2-p-Anisoyl-5-<(4-tolyl)hydroxymethyl>pyrrole 
• 132313-40-7 5,15-Bis(4-fluoro-3-methylphenyl)-10,20-bis(4-methoxyphenyl)porphyrin 
• 132313-41-8 5-(4-Fluoro-3-methylphenyl)-10-(4-methoxyphenyl)-15-(4-tolyl)-20-phenylporphyrin 
• 132313-39-4 5,15-bis-(4-methylphenyl)-10,20-diphenyl-porphyrin 
• 132362-77-7 5-(4-Fluoro-3-methylphenyl)-1-<(4-methoxyphenyl)hydroxymethyl>dipyrromethane 

Relevant articles and documents

A novel, safe, and robust nitration process for the synthesis of 4-(4-methoxy-3-nitrophenyl)morpholine

A novel nitration process was developed for the production of 4-(4-methoxy-3-nitrophenyl)morpholine. Crude 4-(4-methoxyphenyl-)morpholine produced in step 1 was converted to its nitric acid salt. The nitration reaction was carried out by adding a dichloro

SnCl4 and SbCl5 promoted aromatization of enamines

Aromatic amines have been synthesized efficiently from enamines using SnCl4 and SbCl5 in CH2Cl2 at room temperature.

A stable (amino)(phosphino)carbene as bidentate ligand for palladium and nickel complexes: Synthesis, structure, and catalytic activity

Two original complexes featuring an (amino)(phosphino)carbene η2-bonded to the metal have been obtained in 60% and 80% yields, by addition of the corresponding stable carbene to PdCl2(cod) and NiCl2(PPh3)2

A Simple Synthetic Route to Well-Defined [Pd(NHC)Cl(1-tBu-indenyl)] Pre-catalysts for Cross-Coupling Reactions

The development of robust, more efficient, general, easily accessible Pd(II)–NHC pre-catalysts remains a key issue in cross-coupling applications. A selection of well-defined, air and moisture stable [Pd(NHC)Cl(1-tBu-indenyl)] (NHC=IPr, IPrCl, IMes, SIMes, IPr*) pre-catalysts have been synthesized in good to excellent yields by reacting [Pd(1-tBu-indenyl)(μ-Cl)]2 and various NHC?HCl precursors in the presence of the weak base K2CO3 in green acetone. The synthesized Pd(II)-NHC derivatives displayed excellent catalytic activity in classical Suzuki-Miyaura and Buchwald–Hartwig reactions, especially when IPrCl is employed as ancillary ligand. Additionally, in the challenging Suzuki-Miyaura reaction between esters and arylboronic acids, the [Pd(IPr*)Cl(1-tBu-indenyl)] complex exhibited the optimum catalytic activity under very mild reaction conditions.

Selective C-O Bond Reduction and Borylation of Aryl Ethers Catalyzed by a Rhodium-Aluminum Heterobimetallic Complex

We report the catalytic reduction of a C-O bond and the borylation by a rhodium complex bearing an X-Type PAlP pincer ligand. We have revealed the reaction mechanism based on the characterization of the reaction intermediate and deuterium-labeling experiments. Notably, this novel catalytic system shows steric-hindrance-dependent chemoselectivity that is distinct from conventional Ni-based catalysts and suggests a new strategy for selective C-O bond activation by heterobimetallic catalysis.