274-83-9

Basic information

• Product Name: 1,2,4-Triazolo[4,3-b]pyridazine
• Synonyms: 1,2,4-Triazolo[4,3-b]pyridazine;[1,2,4]Triazolo[4,3-b]Pyridazine 1,2,4Triazolo[4,3b]pyridazine;1,2,3a,4Tetraazaindene;2,3,7Triazaindolizine
• CAS NO: 274-83-9
• Molecular Formula: C5H4N4
• Molecular Weight: 120.11
• Mol File: 274-83-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,4-Triazolo[4,3-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazolo[4,3-b]pyridazine(274-83-9)
• EPA Substance Registry System: 1,2,4-Triazolo[4,3-b]pyridazine(274-83-9)

Safety Data

• Hazardous Substances Data: 274-83-9(Hazardous Substances Data)

Usage

General Description

1,2,4-Triazolo[4,3-b]pyridazine is a chemical compound with the molecular formula C6H5N5. It is a heterocyclic compound containing a pyridazine ring fused with a triazole ring. 1,2,4-Triazolo[4,3-b]pyridazine has been investigated for its potential pharmaceutical applications, particularly as a ligand for metal complexes and as a building block for organic synthesis. It exhibits interesting biological activities, including anti-tumor and anti-inflammatory properties, making it a promising candidate for drug development. Additionally, it has been studied for its potential use as a corrosion inhibitor in various industrial applications. Overall, 1,2,4-Triazolo[4,3-b]pyridazine is a versatile chemical compound with potential uses in pharmaceuticals, materials science, and organic synthesis.

Upstream product

• 40972-16-5 3-hydrazinyl pyridazine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 50357-95-4 7,8-dihydro-s-triazolo<4,3-b>pyridazine 
• 73453-19-7 8-Cyclohexyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 73453-24-4 7-Cyclohexyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 73453-25-5 7-Benzyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 73453-20-0 8-Benzyl-[1,2,4]triazolo[4,3-b]pyridazine 
• 87841-07-4 <1,2,4>triazolo<4,3-b>pyridazine-3-aldehyde 

Relevant articles and documents

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Synthesis of [1,2,4]triazolo[4,3-b]pyridazine-3-carboxylic acids

The first synthesis of 6-substituted-[1,2,4]triazolo[4,3-b]pyridazine-3-carboxylic acids 2a-c was carried out by an enzymatic hydrolysis of alkyl 6-substituted-[1,2,4]triazolo[4,3-b]pyridazine-3-carboxylates 1 by α-chymotrypsin (EC 3.4.21.1) immobilized on a polyacrylamide-type bead support (ACRYLEX C-100). Earlier the synthesis of these compounds failed owing to ready decarboxylation of the products. During enzymatic hydrolysis decarboxylation was only a side reaction.