27471-36-9

Basic information

• Product Name: 5-chloro-N-(4-chlorophenyl)pentanamide
• Synonyms: 5-chloro-N-(4-chlorophenyl)pentanamide
• CAS NO: 27471-36-9
• Molecular Weight: 246.136
• Mol File: 27471-36-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-N-(4-chlorophenyl)pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N-(4-chlorophenyl)pentanamide(27471-36-9)
• EPA Substance Registry System: 5-chloro-N-(4-chlorophenyl)pentanamide(27471-36-9)

Safety Data

• Hazardous Substances Data: 27471-36-9(Hazardous Substances Data)

Upstream product

• 4509-90-4 5-bromovaleroyl chloride 
• 106-47-8 4-chloro-aniline 
• 1575-61-7 5-Chlorovaleroyl chloride 

Downstream Products

• 1160748-81-1 5-azido-pentanoic acid (4-chloro-phenyl)-amide 
• 1245641-12-6 N-(4-chlorophenyl)pentamethylenediamine 
• 545445-44-1 5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone 
• 27471-37-0 (2-oxopiperidine-1-yl)chlorobenzene 

Relevant articles and documents

Preparation method of apixaban intermediate

The invention relates to a preparation method of an apixaban intermediate. The preparation method of the apixaban intermediate I comprises the following steps: p-chloroaniline, used as a raw material,and halide undergo an amidation and cyclization reaction under an alkaline condition to obtain 1-(4-chlorophenyl)piperidine-2-one, the 1-(4-chlorophenyl)piperidine-2-one and phosphorus pentachlorideundergo dichloro substitution, condensation-elimination and morpholine substitution to obtain the apixaban intermediate I. The method has the advantages of low cost, high reaction yield, and suitableness for industrial operation.

New synthetic routes for N-substituted 1,n-diamines. II. Synthesis of selectively N-substituted tetra- and pentamethylenediamines from ω-alkanoic acid derivatives

A new approach for the synthesis of selectively N-substituted tetra- and pentamethylenediamines 1 (n = 4,5) is described. The method uses N-substituted ω-haloalkanamides 2 as precursors and involves the microwave-promoted conversion into ω-azidocarboxamides 3 and later the reduction of both azido and carboxamide groups with diborane.