27746-99-2 Usage
Description
2,2,2-Trifluoroethyl chloroformate is an organic compound that serves as a valuable derivatization reagent in the synthesis of various chemical compounds. It is characterized by its ability to react with primary and secondary aliphatic amines, making it a versatile tool in the field of organic chemistry.
Uses
Used in Chemical Synthesis:
2,2,2-Trifluoroethyl chloroformate is used as a derivatization reagent for the production of primary and secondary aliphatic amines. This application is particularly useful in the synthesis of various chemical compounds, such as N-Methylhexadecylamine (M311995), which can be utilized in a wide range of industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,2,2-Trifluoroethyl chloroformate is used as a key intermediate in the synthesis of various drug molecules. Its ability to react with amines makes it a valuable tool in the development of new medications and therapeutic agents.
Used in Research and Development:
2,2,2-Trifluoroethyl chloroformate is also used in research and development settings, where it can be employed to explore new chemical reactions and develop innovative synthetic pathways. This contributes to the advancement of scientific knowledge and the discovery of novel compounds with potential applications in various fields.
Used in Analytical Chemistry:
In analytical chemistry, 2,2,2-Trifluoroethyl chloroformate can be used as a derivatization agent to enhance the detection and analysis of certain compounds. This can be particularly useful in the identification and quantification of amines in complex samples, such as environmental or biological matrices.
Overall, 2,2,2-Trifluoroethyl chloroformate is a versatile and valuable compound with a wide range of applications in various industries, including chemical synthesis, pharmaceuticals, research and development, and analytical chemistry. Its ability to react with primary and secondary aliphatic amines makes it a key component in the production of various chemical compounds and contributes to the advancement of scientific knowledge and the development of new technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 27746-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,7,4 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 27746-99:
(7*2)+(6*7)+(5*7)+(4*4)+(3*6)+(2*9)+(1*9)=152
152 % 10 = 2
So 27746-99-2 is a valid CAS Registry Number.
27746-99-2Relevant articles and documents
Catalytic synthesis of polyfluoroalkyl chloroformates
Rakhimov,Butkovskaya,Baklanov
, p. 1005 - 1006 (2008)
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Cu(II)-promoted methanolysis of N, N -bis(2-picolyl)carbamates: Rate-limiting metal ion delivery of coordinated alcoholate nucleophile followed by fast partitioning of a tetrahedral intermediate
Neverov, Alexei A.,Cimpean, Luana,Chiykowski, Valerie,Vance, Tyler,Brown, R. Stan
, p. 1357 - 1364 (2015/02/19)
Five O-aryl/alkyl N,N-bis(2-picolyl)carbamates were prepared with the O-aryl/alkyl portions being p-nitrophenoxy, m-nitrophenoxy, trifluoroethoxy, methoxy, and isopropoxy (4a,b,c,d,e, respectively) and the kinetics and reaction products of their methanolysis reactions in the presence of Cu(O3SCF3)2 determined. The catalyzed reactions have maximal rates for each substrate at a 1:1 ratio of [4]:[Cu2+] at sspH 7.9, where the active forms are Cu(II):4:(-OCH3). The reactions are fast, that for the complex of 4a having a t1/2 of 30 s. The products of the reaction with 4a and 4b arise exclusively from C-OAr cleavage: those with 4d and 4e arise exclusively from C-N cleavage. With 4c, products from both C-O and C-N cleavage are observed in a 2.17:1 ratio. The common mechanism involves rate-limiting delivery of a Cu(II)-coordinated methoxide to the C=O unit to form a tetrahedral intermediate followed by fast partitioning to products by two pathways with relative barriers dependent on the sspKaHOAr/HOR. The data allow one to predict an effective sspKa of ～15.6 for the sspKaNH of Cu(II):bis(2-picolyl)amine.
A facile synthesis of unsymmetrical ureas
Bogolubsky, Andrey V.,Ryabukhin, Sergey V.,Pipko, Sergey E.,Lukin, Oleg,Shivanyuk, Alexander,Mykytenko, Dmytro,Tolmachev, Andrey
experimental part, p. 3619 - 3623 (2011/06/21)
A facile and versatile method for the synthesis of unsymmetrical ureas from readily available reagents is reported. In the first step trifluoroethylchloroformate is reacted with a stoichiometric amount of a primary amine to give an intermediate trifluoroethyl carbamate. The addition of a second amine (primary or secondary) to the trifluoroethyl carbamate furnishes corresponding unsymmetrical ureas in 75-85% yield. A simple workup procedure, the high yields obtained, and the purity of the isolated products are suitable for the parallel synthesis of combinatorial libraries of unsymmetrical ureas with high structural and functional diversity.
