280748-43-8

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl- (9CI)
• Synonyms: 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl- (9CI);5-Formyl-4-methyl-1H-pyrrole-2-carboxylic acid
• CAS NO: 280748-43-8
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.13538
• Product Categories: GLYCINESCAFFOLD;CARBOXYLICACID;ALDEHYDE
• Mol File: 280748-43-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 389.6°Cat760mmHg
• Flash Point: 189.4°C
• Appearance: /
• Density: 1.414g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl- (9CI)(280748-43-8)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl- (9CI)(280748-43-8)

Safety Data

• Hazardous Substances Data: 280748-43-8(Hazardous Substances Data)

Usage

Derivative of pyrrole

A heterocyclic organic compound The compound is based on the pyrrole structure, which is a five-membered ring containing one nitrogen atom and four carbon atoms.

Contains functional groups

Carboxylic acid and aldehyde The molecule has both a carboxylic acid (-COOH) and an aldehyde (-CHO) functional group, which contribute to its reactivity and potential applications in organic synthesis.

Versatile intermediate

Synthesis of biologically active molecules Due to its unique structure and properties, 1H-Pyrrole-2-carboxylic acid, 5-formyl-4-methyl(9CI) is a valuable intermediate for creating various biologically active compounds, such as pharmaceuticals, agrochemicals, and natural products.

Potential applications

New drug or bioactive compound development The compound's structural features make it a promising candidate for the development of new drugs or bioactive compounds with potential therapeutic or agricultural applications.

InChI:InChI=1/C7H7NO3/c1-4-2-5(7(10)11)8-6(4)3-9/h2-3,8H,1H3,(H,10,11)

Upstream product

• 40611-85-6 4-Methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 26018-26-8 5-formyl-4-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 

Downstream Products

• 865365-23-7 5-(4-ethyl-piperazine-1-carbonyl)-3-methyl-1H-pyrrole-2-carbaldehyde 
• 1236291-24-9 (Z)-5-{6[3-(4-chlorophenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl}-4-methyl-1H-pyrrole-2-carboxylic acid 
• 1236291-23-8 (Z)-4-methyl-5-[2-oxo-6-(3-phenylureido)-1,2-dihydroindol-3-ylidenemethyl]-1H-pyrrole-2-carboxylic acid 
• 346600-00-8 4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-5-[3-METHYL-5-(4-METHYL-PIPERAZINE-1-CARBONYL)-1H-PYRROL-2-YLMETHYLENE]-5,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-6-ONE 
• 346600-38-2 3-methyl-5-(4-methyl-piperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde 
• 346600-08-6 5-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-6-OXO-6,7-DIHYDRO-PYRROLO [2,3-D]PYRIMIDIN-5-YLIDENEMETHYL]-4-METHYL-1H-PYRROLE-2-CARBOXYLIC ACID 

Relevant articles and documents

FORMULATIONS FOR PHARMACEUTICAL AGENTS IONIZABLE AS FREE ACIDS OR FREE BASES

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Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)

The present invention relates generally to the field of radiosensitizing agents which are capable of enhancing radiotherapy by inhibiting DNA-PK (DNA-protein kinase). In particular, it relates to sulfonamide substituted indolinones which inhibit DNA-PK.

Prodrugs of a 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.