28218-55-5

Basic information

• Product Name: 2,5-Anhydro-L-iditol
• Synonyms: 2,5-Anhydro-L-iditol
• CAS NO: 28218-55-5
• Molecular Formula: C₆H₁₂O₅
• Molecular Weight: 164.16
• Mol File: 28218-55-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-Anhydro-L-iditol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Anhydro-L-iditol(28218-55-5)
• EPA Substance Registry System: 2,5-Anhydro-L-iditol(28218-55-5)

Safety Data

• Hazardous Substances Data: 28218-55-5(Hazardous Substances Data)

Usage

Description

2,5-Anhydro-L-iditol, also known as L-idose, is a rare sugar alcohol belonging to the class of sugar alcohols. It is naturally found in some plants and fungi and is primarily used in the pharmaceutical industry due to its potential therapeutic properties.
Used in Pharmaceutical Industry:
2,5-Anhydro-L-iditol is used as an inhibitor of glycosidase enzymes for its potential applications in the treatment of various metabolic disorders.
2,5-Anhydro-L-iditol is also used as an antioxidant and anti-inflammatory agent for its potential applications in preclinical studies, with further research needed to fully understand its potential uses and effectiveness.

Upstream product

• 32445-71-9 2,5-Anhydro-1-O-tosyl-L-iditol 
• 535-94-4 β-D-Glcp-(1->4)-D-glucitol 
• 68774-47-0 2,5-anhydro-1,6-di-O-trityl-DL-altritol 
• 23261-20-3 1,2:5,6-dianhydrogalactitol 
• 50-70-4 D-sorbitol 

Downstream Products

• 32445-72-0 1,6-di-O-(p-toluenesulfonyl)-2,5-anhydro-L-iditol 
• 303764-57-0 MeO-Leu-Phe-Idac(Bn₂)-Phe-Leu-OMe 
• 303764-58-1 MeO-Leu-Phe-Idac-Phe-Leu-OMe 
• 303764-48-9 Boc-Iaa(Bn₂)-Phe-Leu-OMe 
• 303764-34-3 2,5-anhydro-3,4-di-O-benzyl-1,6-di-O-(tert-butyldiphenylsilyl)-D-iditol 
• 303764-35-4 2,5-anhydro-3,4-di-O-benzyl-6-O-tosyl-D-iditol 
• 303764-37-6 ((2S,3R,4R,5S)-3,4-Bis-benzyloxy-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl)-carbamic acid tert-butyl ester 
• 303764-56-9 2,5-anhydro-3,4-di-O-benzyl-D-idaric acid 
• 303764-36-5 2,5-anhydro-6-azido-3,4-di-O-benzyl-D-iditol 
• 222960-51-2 2,5-anhydro-3,4-di-O-benzyl-L-iditol 
• 667426-89-3 1,6-di-O-(triphenylmethyl)-2,5-anhydro-L-iditol 
• 303764-33-2 2,5-anhydro-1,6-di-O-(tert-butyldiphenylsilyl)-D-iditol 

Relevant articles and documents

Effect of carbon chain length on catalytic C–O bond cleavage of polyols over Rh-ReOx/ZrO2 in aqueous phase

Production of linear deoxygenated C4 (butanetriols, -diols, and butanols), C5 (pentanetetraols, -triols, -diols, and pentanols), and C6 products (hexanepentaols, -tetraols, -triols, -diols, and hexanols) is achievable by hydrogenolysis of erythritol, xylitol, and sorbitol over supported-bimetallic Rh-ReOx (Re/Rh molar ratio 0.5) catalyst, respectively. After validation of the analytical methodology, the effect of some reaction parameters was studied. In addition to C–O bond cleavage by hydrogenolysis, these polyols can undergo parallel reactions such as epimerization, cyclic dehydration, and C–C bond cleavage. The time courses of each family of linear deoxygenated C4, C5, and C6 products confirmed that the sequence of appearance of the different categories of deoxygenated products followed a multiple sequential deoxygenation pathway. The highest selectivity to a mixture of linear deoxygenated C4, C5, and C6 products at 80percent conversion was favoured under high pressure in the presence of 3.7wt.percentRh-3.5wt.percentReOx/ZrO2 catalysts (54–71percent under 80 bar) at 200 °C.

THE CHEMICAL-TRANSFORMATION PRODUCTS OF 1,6-DIBROMO-1,6-DIDEOXYGALACTITOL AND 1,2:5,6-DIANHYDROGALACTITOL IN AQUEOUS SOLUTION

After hydrolysis of 1,6-dibromo-1,6-dideoxygalactitol (1) and 1,2:5,6-dianhydrogalactitol (2), 11 compounds were isolated, three of them as tritylated derivatives.Their structures were established on the basis of chemical evidence and, for four compounds, by X-ray diffraction.The main product of the hydrolysis of 1 was 3,6-anhydro-1-bromo-1-deoxy-DL-galactitol; the end-products of the hydrolysis of 2 were 1,5-anhydro-DL-galactitol, 2,5-anhydro-DL-altriol and galactiotol.