284469-97-2Relevant articles and documents
Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete
Yokokawa, Fumiaki,Izumi, Kentaro,Omata, Junko,Shioiri, Takayuki
, p. 3027 - 3034 (2000)
Amamistatin A, a linear lipopeptide and a growth inhibitor of human tumor cell lines from an actinomycete, was efficiently synthesized by a convergent approach. The asymmetric synthesis of β-hydroxy acid fragment was achieved by using chiral oxazaborolidinone mediated aldol reaction. The oxazole ring was constructed from N-acylthreonine via side-chain oxidation and cyclodehydration. The synthesis of the linear peptide was carded out in a stepwise manner from the cyclic hydroxamic acid fragment, and the final deprotection provided amamistatin A. (C) 2000 Elsevier Science Ltd.