28525-13-5

Basic information

• Product Name: 4-(phenylsulfonyl)benzonitrile
• Synonyms: 4-(phenylsulfonyl)benzonitrile
• CAS NO: 28525-13-5
• Molecular Formula: C₁₃H₉NO₂S
• Molecular Weight: 243.28106
• Mol File: 28525-13-5.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(phenylsulfonyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(phenylsulfonyl)benzonitrile(28525-13-5)
• EPA Substance Registry System: 4-(phenylsulfonyl)benzonitrile(28525-13-5)

Safety Data

• Hazardous Substances Data: 28525-13-5(Hazardous Substances Data)

Usage

Description

4-(phenylsulfonyl)benzonitrile is a chemical compound that features a benzene ring with a nitrile group and a sulfone group attached to it. It is recognized for its potential pharmacological activities, such as anti-inflammatory and analgesic properties, and is valued in the field of medicinal chemistry for its role in treating certain diseases and conditions.

Uses

Used in Pharmaceutical Industry:
4-(phenylsulfonyl)benzonitrile is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and potential pharmacological activities.
Used in Agrochemical Industry:
4-(phenylsulfonyl)benzonitrile is utilized as a precursor in the development of agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Dye and Pigment Industry:
4-(phenylsulfonyl)benzonitrile is employed as a component in the production of dyes and pigments, taking advantage of its chemical properties to enhance color characteristics.
Used in Material Science:
It serves as a key intermediate in the synthesis of functional materials, where its unique structure contributes to the development of advanced materials with specific properties.
Used in Medicinal Chemistry Research:
4-(phenylsulfonyl)benzonitrile is used as a research compound for exploring its potential role in treating certain diseases and conditions, highlighting its importance in the advancement of medical treatments.

Upstream product

• 98-10-2 benzenesulfonamide 
• 5361-54-6 4-(phenylsulfonyl)benzoic acid 
• 55204-60-9 4-benzenesulfonyl-benzoic acid amide 
• 1194-02-1 4-fluorobenzonitrile 
• 873-55-2 sodium benzenesulfonate 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 111278-48-9 C₁₈H₁₄N₂O₂S₂ 
• 623-00-7 4-bromobenzenecarbonitrile 
• 141212-52-4 (phenylsulphonyl)phenyl-3-mercapto-1,2,4-triazole 
• 108-98-5 thiophenol 
• 51238-46-1 4-(phenylthio)benzonitrile 
• 66-39-7 4-(phenylsulfonyl)benzaldehyde 
• 3058-39-7 4-iodobenzonitrile 
• 98-80-6 phenylboronic acid 

Downstream Products

• 5585-14-8 3,4-diphenyl-furazan 2-oxide 
• 111797-44-5 5-(4-benzenesulfonyl-phenyl)-3-phenyl-[1,2,4]oxadiazole 
• 65085-83-8 4'-(phenylsulfonyl)acetophenone 
• 66-39-7 4-(phenylsulfonyl)benzaldehyde 
• 94341-56-7 [4-(benzenesulfonyl)phenyl]methanamine 
• 37991-83-6 4-(phenylsulfonyl)benzoyl chloride 
• 5361-54-6 4-(phenylsulfonyl)benzoic acid 
• 1363155-27-4 N-(imidazo[1,2-a]pyridin-6-ylmethyl)-4-(phenylsulfonyl)benzamide 
• 1362752-18-8 2-cyano-1-(imidazo[1,2-a]pyridin-7-yl)-3-(4-(phenylsulfonyl)benzyl)guanidine 
• 1362752-20-2 2-cyano-1-(imidazo[1,2-a]pyridin-7-ylmethyl)-3-(4-(phenylsulfonyl)benzyl)guanidine 
• 1362752-16-6 2-cyano-1-(4-(phenylsulfonyl)benzyl)-3-(pyridin-3-yl)guanidine 
• 4779-37-7 2-bromo-1-(4-(phenylsulfonyl)phenyl)ethan-1-one 
• 1520089-89-7 tert-butyldimethyl(phenyl(4-(phenylsulfonyl)phenyl)methoxy)silane 
• 1440419-03-3 tert-butyl 2-(4-cyanophenyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Visible-Light-Mediated Late-Stage Sulfonylation of Boronic Acids via N-S Bond Activation of Sulfonamides

A visible-light-mediated late-stage arylation of N-S bonds in sulfonamides has been developed with using readily available imines as sulfonyl radical source. Diverse complex sulfones could be synthesized by prefunctionalizaiton and subsequent N-S bond ary

Ceramic boron carbonitrides for unlocking organic halides with visible light

Photochemistry provides a sustainable pathway for organic transformations by inducing radical intermediates from substrates through electron transfer process. However, progress is limited by heterogeneous photocatalysts that are required to be efficient, stable, and inexpensive for long-term operation with easy recyclability and product separation. Here, we report that boron carbonitride (BCN) ceramics are such a system and can reduce organic halides, including (het)aryl and alkyl halides, with visible light irradiation. Cross-coupling of halides to afford new C-H, C-C, and C-S bonds can proceed at ambient reaction conditions. Hydrogen, (het)aryl, and sulfonyl groups were introduced into the arenes and heteroarenes at the designed positions by means of mesolytic C-X (carbon-halogen) bond cleavage in the absence of any metal-based catalysts or ligands. BCN can be used not only for half reactions, like reduction reactions with a sacrificial agent, but also redox reactions through oxidative and reductive interfacial electron transfer. The BCN photocatalyst shows tolerance to different substituents and conserved activity after five recycles. The apparent metal-free system opens new opportunities for a wide range of organic catalysts using light energy and sustainable materials, which are metal-free, inexpensive and stable. This journal is

Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis

An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates is reported. In our protocol, a single ligand CuI photocatalyst formed in situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrates a promising approach toward the synthesis of diverse and useful organosulfones.