28533-43-9

Basic information

• Product Name: 4-Formamido Benzoic Acid
• Synonyms: 4-(Formylamino)benzoic Acid;4-Formamido Benzoic Acid;NSC 3009;p-Formamidobenzoic Acid;NSC 30096
• CAS NO: 28533-43-9
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.15
• Product Categories: Chemical Amines;Amines;Aromatics
• Mol File: 28533-43-9.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 428.6°Cat760mmHg
• Flash Point: 213°C
• Appearance: /
• Density: 1.39g/cm³
• Vapor Pressure: 4.14E-08mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 4-Formamido Benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Formamido Benzoic Acid(28533-43-9)
• EPA Substance Registry System: 4-Formamido Benzoic Acid(28533-43-9)

Safety Data

• Hazardous Substances Data: 28533-43-9(Hazardous Substances Data)

Usage

Description

4-Formamido Benzoic Acid, with the CAS number 28533-43-9, is an organic compound that is characterized by its white to off-white solid appearance. It is widely recognized for its utility in various organic synthesis processes, making it a valuable component in the field of chemistry.

Uses

Used in Organic Synthesis:
4-Formamido Benzoic Acid is used as a key intermediate for the synthesis of various organic compounds. Its unique chemical structure allows it to participate in a range of reactions, facilitating the creation of diverse molecules with different applications across various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Formamido Benzoic Acid is utilized as a building block for the development of new drugs. Its reactivity and structural versatility make it an essential component in the design and synthesis of novel therapeutic agents.
Used in Chemical Research:
4-Formamido Benzoic Acid is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic pathways. Its use in research contributes to the advancement of chemical knowledge and the development of innovative chemical processes.
Used in Material Science:
In the field of material science, 4-Formamido Benzoic Acid is used as a component in the development of new materials with specific properties. Its incorporation into the synthesis of these materials can lead to the creation of materials with enhanced characteristics, such as improved stability or reactivity.
Overall, 4-Formamido Benzoic Acid is a versatile compound with a wide range of applications across different industries, including organic synthesis, pharmaceuticals, chemical research, and material science. Its unique properties and reactivity make it an essential tool in the development of new compounds and materials with various potential uses.

InChI:InChI=1/C8H7NO3/c10-5-9-7-3-1-6(2-4-7)8(11)12/h1-5H,(H,9,10)(H,11,12)

Upstream product

• 64-18-6 formic acid 
• 150-13-0 4-amino-benzoic acid 
• 22669-27-8 p-aminobenzoic acid hydrochloride 
• 77287-34-4 formamide 
• 2258-42-6 formyl acetic anhydride 
• 62-23-7 4-nitro-benzoic acid 
• 109-94-4 formic acid ethyl ester 
• 14047-29-1 4-carboxyphenylboronic acid 
• 106-40-1 4-bromo-aniline 
• 16712-16-6 ammonium formate 
• 201230-82-2 carbon monoxide 
• 2617-78-9 N-(4-bromophenyl)formamide 
• 107-31-3 Methyl formate 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 847369-43-1 4-Isocyano-benzoic acid 4-((R)-1-methyl-heptyloxy)-3-nitro-phenyl ester 
• 175887-28-2 (R)-4-[1-(methylheptyl)oxy]phenyl 4-isocyanobenzoate 
• 24170-25-0 4-formylamino-3-nitro-benzoyl chloride 
• 22669-27-8 p-aminobenzoic acid hydrochloride 

Relevant articles and documents

HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media

We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.

Design, synthesis, antibacterial, and antitumor activity of linear polyisocyanide quaternary ammonium salts with different structures and chain lengths

The development of organic polymer materials for disinfection and sterilization is thought of as one of the most promising avenues to solve the growth and spread of harmful microorgan-isms. Here, a series of linear polyisocyanide quaternary ammonium salts (L-PQASs) with different structures and chain lengths were designed and synthesized by polymerization of phenyl isocyanide monomer containing a 4-chloro-1-butyl side chain followed by quaternary amination salinization. The resultant compounds were characterized by1H NMR and FT-IR. The antibacterial activity of L-PQASs with different structures and chain lengths against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by determining the minimum inhibitory concentrations (MICs). The L-POcQAS-M50 has the strongest antimicrobial activity with MICs of 27 μg/mL against E. coli and 32 μg/mL against S. aureus. When the L-PQASs had the same polymerization degree, the order of the antibacterial activity of the L-PQASs was L-POcQAS-Mn > L-PBuQAS-Mn > L-PBnQAS-Mn > L-PDBQAS-Mn (linear, polyisocyanide quaternary ammonium salt, monomer, n = 50,100). However, when L-PQASs had the same side chain, the antibacterial activity reduced with the increase of the molecular weight of the main chain. These results demonstrated that the antibacterial activity of L-PQASs was dependent on the structure of the main chain and the length of the side chain. In addition, we also found that the L-POcQAS-M50 had a significant killing effect on MK-28 gastric cancer cells.

Chiral diolefin rhodium metal catalyst as well as preparation method and application thereof

The invention relates to a chiral diene rhodium metal catalyst and a preparation method and application thereof and belongs to the field of catalysts. The preparation method includes: dropwisely adding dimethyl aluminum chloride solution into (-)-alpha-ph