28649-59-4

Basic information

• Product Name: Euphorbiasteroid
• Synonyms: 6,20-Epoxylathyrol phenylacetate diacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees
• CAS NO: 28649-59-4
• Molecular Formula: C32H40O8
• Molecular Weight: 552.66
• Mol File: 28649-59-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 199～200℃
• Boiling Point: 633.1°Cat760mmHg
• Flash Point: 263.9°C
• Appearance: /
• Density: 1.23
• CAS DataBase Reference: Euphorbiasteroid(CAS DataBase Reference)
• NIST Chemistry Reference: Euphorbiasteroid(28649-59-4)
• EPA Substance Registry System: Euphorbiasteroid(28649-59-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 28649-59-4(Hazardous Substances Data)

Usage

Description

Euphorbiasteroid is a bioactive compound derived from the Euphorbia plant family, known for its unique properties and potential applications in various fields. It possesses the ability to induce apoptosis in certain cell types, making it a subject of interest for research and development.

Uses

Used in Pharmaceutical Applications:
Euphorbiasteroid is used as an apoptosis-inducing agent for promoting the Bcl/Bax apoptotic signaling pathway in a dose-dependent manner. This property makes it a potential candidate for the development of treatments targeting cancer cells, as it can selectively induce apoptosis in malignant cells while sparing healthy ones.
Used in Cancer Research:
In the field of cancer research, Euphorbiasteroid is utilized to study the mechanisms of apoptosis and the potential for developing targeted therapies against various types of cancer. Its ability to activate the Bcl/Bax signaling pathway provides valuable insights into the processes underlying cell death and the development of more effective cancer treatments.
Used in Drug Delivery Systems:
Similar to gallotannin, Euphorbiasteroid may also benefit from the development of novel drug delivery systems to enhance its applications and efficacy against cancer cells. By employing various organic and metallic nanoparticles as carriers, the delivery, bioavailability, and therapeutic outcomes of Euphorbiasteroid could be significantly improved, making it a more viable option for cancer treatment.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect. Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.