288-90-4 Usage
Description
1,2,4-Oxadiazole is a five-membered, planar, conjugated, nonbenzonoid, aromatic heterocyclic system comprised of one oxygen atom and two nitrogen atoms at positions 2 and 4 of the oxadiazole ring. The oxadiazole ring has two pyridine-like nitrogen atoms. Positions 3 and 5 are vulnerable for nucleophilic substitution to form 3,5-disubstituted 1,2,4-oxadiazoles. The topography of the 1,2,4-oxadiazole ring reveals that it has a more heterodiene character compared to its aromatic nature. The substituted 1,2,4-oxadiazole ring system was first reported in 1880 but the parent 1,2,4-oxadiazole was not reported until 1962 because of instability of the molecule.
Uses
Used in Biological Studies:
1,2,4-Oxadiazole is used as a compound in the biological study of antitubercular activity of butyrate-specific oxadiazoles against Mycobacterium tuberculosis and their cytotoxicity on monkey kidney cells. This application is significant for the development of new antitubercular drugs and understanding the potential side effects on other cells.
Used in Pharmaceutical Industry:
1,2,4-Oxadiazole is used as a building block for the synthesis of various pharmaceutical compounds due to its unique chemical properties and reactivity. The ability to form 3,5-disubstituted 1,2,4-oxadiazoles makes it a versatile component in the design and synthesis of new drugs with potential applications in various therapeutic areas.
Used in Chemical Research:
1,2,4-Oxadiazole is used as a subject of study in chemical research to understand its physical properties, such as its stability, reactivity, and the chemical shifts observed in the 13C NMR spectra. This knowledge can be applied to improve the synthesis methods and explore new applications for 1,2,4-oxadiazole and its derivatives in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 288-90-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 288-90:
(5*2)+(4*8)+(3*8)+(2*9)+(1*0)=84
84 % 10 = 4
So 288-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C2H2N2O/c1-3-2-5-4-1/h1-2H
288-90-4Relevant articles and documents
Lipopeptide Compounds and Their Use
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, (2011/10/04)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain lipopeptide compounds comprising a cyclic peptide bearing a lipid side chain (for convenience, collectively referred to herein as “LP compounds”), which, inter alia, are antimicrobial, particularly antibacterial. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to provide an antimicrobial function, particularly an antibacterial function, and in the treatment of diseases and conditions that are mediated by microbes, particularly bacteria, that are ameliorated by the antimicrobial function, particularly an antibacterial function, including bacterial diseases, optionally in combination with another agent, for example, another antibacterial agent.
Trisubstituted heterocyclic compounds and their use as fungicides
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, (2008/06/13)
Compounds of general formula (I): in which:Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted in an adjacent manner with -P-Q1-T-Q2, -GZ and Y, such that the substituant -GZ is adjacent to both. the other substituants being as defined in the description,process for preparing these compounds,fungicidal compositions comprising these compounds,processes for treating plants by applying these compounds or compositions.
Heteroaryl-phenyl substituted factor Xa inhibitors
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, (2008/06/13)
The present application describes heteroaryl-phenyl substituted compounds and derivatives thereof, or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of factor Xa.
