2898-19-3Relevant articles and documents
Process for preparing 1,4-benzodiazepines
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, (2008/06/13)
1,4-Benzodiazepine derivatives of the formula, STR1 wherein R1 is hydrogen, a lower alkyl, a haloalkyl, a cycloalkylalkyl, an alkoxyalkyl, an acyloxyalkyl, an alkylthioalkyl, an alkylaminoalkyl, a dialkylaminoalkyl, a hydroxyalkyl, carbamoyl, or an N-alkylcarbamoyl; R2 is hydrogen or a lower alkyl; X is hydrogen, a halogen, nitro, or trifluoromethyl; A is a group of the formula, STR2 (wherein Y and Z each represent hydrogen, a halogen, a lower alkyl, or nitro) and a salt thereof, are prepared by reacting a 1,4-benzodiazepin-2-one compound of the formula, STR3 wherein R1, R2, X, Y and Z are the same as defined above, with diborane in an inert solvent.