28987-48-6

Basic information

• Product Name: 4-ETHOXY-2-FLUORO-1-NITROBENZENE
• Synonyms: 4-ETHOXY-2-FLUORO-1-NITROBENZENE;4-Ethoxy-2-fluoronitrobenzene;4-Ethoxy-2-fluoronitrobenzene 98%;4-Ethoxy-2-fluoronitrobenzene98%
• CAS NO: 28987-48-6
• Molecular Formula: C₈H₈FNO₃
• Molecular Weight: 185.15
• Product Categories: blocks;FluoroCompounds;NitroCompounds
• Mol File: 28987-48-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 47-49
• Boiling Point: 278.3°Cat760mmHg
• Flash Point: 122.1°C
• Appearance: /
• Density: 1.268g/cm³
• Vapor Pressure: 0.00726mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-ETHOXY-2-FLUORO-1-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHOXY-2-FLUORO-1-NITROBENZENE(28987-48-6)
• EPA Substance Registry System: 4-ETHOXY-2-FLUORO-1-NITROBENZENE(28987-48-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 28987-48-6(Hazardous Substances Data)

Usage

General Description

4-Ethoxy-2-fluoro-1-nitrobenzene is a chemical compound with the molecular formula C8H7FNO3. It is a pale yellow solid with the functional groups of ethoxy, fluorine, and nitro attached to a benzene ring. 4-ETHOXY-2-FLUORO-1-NITROBENZENE is used in chemical synthesis and organic reactions, and its structure and properties make it a valuable building block for the production of various compounds. Its main applications include pharmaceuticals, agrochemicals, and materials science. However, it is important to handle it with caution, as it may be hazardous if not used properly.

InChI:InChI=1/C8H8FNO3/c1-2-13-6-3-4-8(10(11)12)7(9)5-6/h3-5H,2H2,1H3

Upstream product

• 64-67-5 diethyl sulfate 
• 394-41-2 3-fluoro-4-nitrophenol 
• 75-03-6 ethyl iodide 
• 446-35-5 2,4-Difluoronitrobenzene 
• 141-52-6 sodium ethanolate 
• 917-58-8 potassium ethoxide 

Downstream Products

• 1446338-17-5 (2-amino-5-ethoxyphenyl)(2-methylpropyl)amine 
• 1446338-18-6 2-(4-chlorophenoxy)-N-{4-ethoxy-2-[(2-methylpropyl)amino]phenyl}acetamide 
• 1446337-69-4 4-chloro-1-{[6-ethoxy-1-(2-methylpropyl)benzimidazole-2-yl]methoxy}benzene 
• 1446338-20-0 N-{4-ethoxy-2-[(2-methylpropyl)amino]phenyl}-2(phenylamino)acetamide 
• 1446337-71-8 {[6-ethoxy-1-(2-methylpropyl)benzimidazole-2-yl]methyl}phenylamine 
• 950773-13-4 4-(ethyloxy)-N₂-{1-[trans-1-methyl-4-(ethyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine 
• 950773-11-2 4-(ethyloxy)-N₂-{1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine 
• 1041259-36-2 methyl 2-(2-chlorophenyl)-2-(5-ethoxy-2-nitrophenyl)butyrate 
• 1032816-53-7 2-(2-chloro-phenyl)-2-(5-ethoxy-2-nitro-phenyl)methyl propionate 
• 625119-94-0 tert-butyl 4-(5-ethoxy-2-nitrophenyl)piperazine-1-carboxylate 
• 950773-12-3 N-[5-(ethyloxy)-2-nitrophenyl]-1-[trans-1-methyl-4-(ethyloxy)cyclohexyl]-4-piperidinamine 
• 950773-10-1 N-[5-(ethyloxy)-2-nitrophenyl]-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine 

Relevant articles and documents

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I), salts and solvates are provided: formula (I), wherein Q, R and R6 are as defined in the claims. Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. VI. ORIENTATION IN THE REACTIONS OF 2,4-DIFLUORONITROBENZENE WITH ALKALI-METAL ALCOHOLATES AND PHENOLATES

On the basis of the results from a study of the orientation during the substitution of a fluorine atom in 2,4-difluoronitrobenzene by the action of nucleophiles of the ROM type (R = Me, Et, i-Pr, Ph; M = Na, K) and its temperature dependence for the reactions with sodium methoxide and sodium phenolate in liquid ammonia at -70 to -33 deg C it was shown that the enthalpy control of the ratio of the substitution rates of the fluorine atoms at the ortho and para positions to the nitro group, which was previously found in the reactions of o- and p-fluoronitrobenzenes with sodium methoxide in liquid ammonia, is general.It was shown that the preference for substitution at the ortho position under these conditions increases with change in the nature of the alcoholate in the order MeO- - -.This is evidently due primarily to the increase in the polarizability of the alkyl group of alcoholate in the same order.