28987-50-0

Basic information

• Product Name: 2-Fluoro-4-isopropoxy-1-nitrobenzene
• Synonyms: 2-Fluoro-4-isopropoxy-1-nitrobenzene
• CAS NO: 28987-50-0
• Molecular Formula: C₉H₁₀FNO₃
• Molecular Weight: 199.1790032
• Mol File: 28987-50-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 285.3±20.0 °C(Predicted)
• Appearance: /
• Density: 1.222±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Fluoro-4-isopropoxy-1-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-isopropoxy-1-nitrobenzene(28987-50-0)
• EPA Substance Registry System: 2-Fluoro-4-isopropoxy-1-nitrobenzene(28987-50-0)

Safety Data

• Hazardous Substances Data: 28987-50-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-isopropoxy-1-nitrobenzene is a chemical compound with the molecular formula C9H10FNO3. It is a colorless to light yellow liquid with a molecular weight of 181.18 g/mol. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the manufacturing of dyes, perfumes, and other organic compounds. Due to its nitro and fluoro functional groups, it has the potential to be hazardous if not handled properly and should be stored and used with caution in a controlled laboratory setting or industrial environment.

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 683-60-3 sodium isopropylate 
• 6831-82-9 potassium isopropoxide 
• 75-30-9 2-iodo-propane 
• 446-38-8 2-fluoro-4-methoxy-1-nitro-benzene 
• 394-41-2 3-fluoro-4-nitrophenol 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 154080-04-3 2-fluoro-4-isopropoxyaniline 
• 932701-01-4 1,1-dimethylethyl 4-({5-[(1-methylethyl)oxy]-2-nitrophenyl}amino)-1-piperidinecarboxylate 

Relevant articles and documents

BENZIMIDAZOLONES WHICH HAVE ACTIVITY AT Ml RECEPTOR

Compounds of formula (I) and salts and solvates are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. VI. ORIENTATION IN THE REACTIONS OF 2,4-DIFLUORONITROBENZENE WITH ALKALI-METAL ALCOHOLATES AND PHENOLATES

On the basis of the results from a study of the orientation during the substitution of a fluorine atom in 2,4-difluoronitrobenzene by the action of nucleophiles of the ROM type (R = Me, Et, i-Pr, Ph; M = Na, K) and its temperature dependence for the reactions with sodium methoxide and sodium phenolate in liquid ammonia at -70 to -33 deg C it was shown that the enthalpy control of the ratio of the substitution rates of the fluorine atoms at the ortho and para positions to the nitro group, which was previously found in the reactions of o- and p-fluoronitrobenzenes with sodium methoxide in liquid ammonia, is general.It was shown that the preference for substitution at the ortho position under these conditions increases with change in the nature of the alcoholate in the order MeO- - -.This is evidently due primarily to the increase in the polarizability of the alkyl group of alcoholate in the same order.