2901-45-3 Usage
Description
[4-(acetylamino)cyclohexyl]acetic acid, with the chemical formula C12H19NO3, is a cyclohexylacetic acid derivative featuring a cyclohexyl ring with an acetylamino group at the 4-position and a carboxylic acid group at the alpha position. [4-(acetylamino)cyclohexyl]acetic acid is recognized for its anti-inflammatory and analgesic properties, positioning it as a promising candidate for the development of therapeutic agents targeting pain management and related conditions. Its unique structural attributes also render it a valuable subject for medicinal chemists in the design of novel compounds with enhanced pharmacological profiles.
Uses
Used in Pharmaceutical Industry:
[4-(acetylamino)cyclohexyl]acetic acid is utilized as a building block for the synthesis of various drugs and drug candidates. Its anti-inflammatory and analgesic properties make it a potential candidate for the development of new therapeutic agents aimed at pain management and related conditions.
Used in Medicinal Chemistry:
The structural features of [4-(acetylamino)cyclohexyl]acetic acid make it a valuable target for medicinal chemists in the design of novel compounds with improved pharmacological profiles, potentially leading to the creation of more effective drugs for a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2901-45-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,0 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2901-45:
(6*2)+(5*9)+(4*0)+(3*1)+(2*4)+(1*5)=73
73 % 10 = 3
So 2901-45-3 is a valid CAS Registry Number.
2901-45-3Relevant articles and documents
Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents
Johnston,McCaleb,Clayton,Frye,Krauth,Montgomery
, p. 279 - 290 (2007/10/04)
The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.
