2902-69-4

Basic information

• Product Name: 2,2,2-trichloroacetophenone
• Synonyms: 2,2,2-trichloroacetophenone;Ethanone, 2,2,2-trichloro-1-phenyl-;2,2,2-trichloro-1-phenyl-Ethanone;Trichloro phenyl ethyl ketone
• CAS NO: 2902-69-4
• Molecular Formula: C₈H₅Cl₃O
• Molecular Weight: 223.4837
• EINECS: 1312995-182-4
• Mol File: 2902-69-4.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 320.3°C (rough estimate)
• Flash Point: 68.8°C
• Appearance: /
• Density: 1.4250
• Vapor Pressure: 0.816mmHg at 25°C
• Refractive Index: 1.5510 (estimate)
• CAS DataBase Reference: 2,2,2-trichloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trichloroacetophenone(2902-69-4)
• EPA Substance Registry System: 2,2,2-trichloroacetophenone(2902-69-4)

Safety Data

• Hazardous Substances Data: 2902-69-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3952, 1950 DOI: 10.1021/ja01165a032

InChI:InChI=1/C5H10OS/c1-2-7-5-3-4-6/h4H,2-3,5H2,1H3

Upstream product

• 545-06-2 trichloroacetonitrile 
• 71-43-2 benzene 
• 7647-01-0 hydrogenchloride 
• 7446-70-0 aluminium trichloride 
• 2000-43-3 2,2,2-trichloro-1-phenylethanol 
• 76-02-8 trifluoroacetyl chloride 
• 7791-25-5 sulfuryl dichloride 
• 98-86-2 acetophenone 
• 7782-50-5 chlorine 
• 637-44-5 phenylpropyolic acid 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 75-87-6 chloral 

Downstream Products

• 1759-68-8 N-benzoylcyclohexylamine 
• 94-33-7 C₉H₁₀O₃ 
• 94-49-5 1,2-ethanediol, dibenzoate 
• 98128-33-7 phosphoric acid diethyl ester-(2,2-dichloro-1-phenyl-vinyl ester) 
• 879-71-0 N-2-butylbenzamide 
• 634-42-4 N-1-naphthalenyl-benzamide 
• 5440-69-7 N-isopropylbenzamide 
• 67-66-3 chloroform 
• 93-58-3 benzoic acid methyl ester 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 65-85-0 benzoic acid 
• 88070-48-8 N-methylbenzamide 
• 113446-39-2 dimethyldi(1-phenyl-2,2-dichlorovinyloxy)silane 
• 644-33-7 N,N'-ethanediyl-bis-benzamide 

Relevant articles and documents

Synthesis of Trihalomethyl Ketones from Trihalomethyl Carbinols (Hal = Cl, Br) Using 2-Iodoxybenzoic Acid

Abstract: An efficient method for the preparation of trihalomethyl (Cl, Br) ketones by the oxidation of trihalomethyl carbinols with 2-iodoxybenzoic acid in tert-butanol under heating has been developed. A series of trihalomethyl ketones have been synthesized through a simple, convenient, and environmentally friendly method with excellent yields.

(R)-2,2,2-trichloro-1-phenylethyl (methylsulfonyl)-oxycarbamate

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Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application

A continuous flow reaction system was developed for the synthesis of 2,2,2-trichloroacetophenone derivatives. When aryl propiolic acids and water were mixed with trichloroisocyanuric acid in DMF at 5 °C, the 2,2,2-trichloroacetophenone derivatives were formed within 5 min with good yields. In addition, the resulting mixture was flowed to react with amines to give the corresponding benzamide. This flow reaction system provided higher yields within shorter times than the batch reaction system.