29124-56-9

Basic information

• Product Name: 1-(2-amino-5-bromophenyl)ethanone
• Synonyms: 1-(2-amino-5-bromophenyl)ethanone;2'-Amino-5'-bromoacetophenone;1-(2-aMino-5-broMophenyl)ethan-1-one
• CAS NO: 29124-56-9
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.06
• Mol File: 29124-56-9.mol
• Article Data: 46

Chemical Properties

• Melting Point: 86-88 °C
• Boiling Point: 302.244 °C at 760 mmHg
• Flash Point: 136.592 °C
• Appearance: /
• Density: 1.535 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.60±0.10(Predicted)
• CAS DataBase Reference: 1-(2-amino-5-bromophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-5-bromophenyl)ethanone(29124-56-9)
• EPA Substance Registry System: 1-(2-amino-5-bromophenyl)ethanone(29124-56-9)

Safety Data

• Hazardous Substances Data: 29124-56-9(Hazardous Substances Data)

Usage

General Description

1-(2-amino-5-bromophenyl)ethanone is a chemical compound with the chemical formula C8H8BrNO. It is an organic ketone that contains a bromine atom, an amino group, and a phenyl group. 1-(2-amino-5-bromophenyl)ethanone is commonly used in organic synthesis and pharmaceutical research as a key intermediate for the synthesis of various drugs. It has also shown potential as a building block for the development of new materials and has been used in the production of dyes and other organic compounds. Due to its unique structure and functional groups, 1-(2-amino-5-bromophenyl)ethanone has been the subject of numerous studies and research efforts aiming to explore its potential applications in various fields.

Upstream product

• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 613-89-8 2-Aminoacetophenone 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 75-16-1 methylmagnesium bromide 
• 41877-24-1 1-(5-bromo-2-nitrophenyl)ethane-1-one 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 676-58-4 methylmagnesium chloride 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 
• 917-54-4 methyllithium 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 75-05-8 acetonitrile 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 876-88-0 6-bromo-1H-cinnolin-4-one 
• 84-40-2 5,5'-dibromo-1H,1'H-[2,2']biindolylidene-3,3'-dione 
• 201420-31-7 6-bromo-4-chloroquinoline-3-carbaldehyde 
• 1020576-91-3 ethyl 2-((2-acetyl-4-bromophenyl)amino)-2-oxoacetate 
• 937817-49-7 (2-acetyl-4-bromophenylamino)acetic acid ethyl ester 
• 1010684-14-6 N-(2-acetyl-4-bromophenyl)glycine 
• 1160304-69-7 1-(2-amino-5-bromophenyl)ethanone O-phenyl oxime 
• 29124-64-9 N-(2-acetyl-4-bromophenyl)acetamide 
• 1569432-28-5 1-acetyl-5-Br-2-phenyl-2,3-dihydroquinolin-4(1H)-one 
• 194782-61-1 4-bromo-2-(prop-1-en-2-yl)aniline 

Relevant articles and documents

In vitro cytotoxicity of novel 2,5,7-tricarbo-substituted indoles derived from 2-amino-5-bromo-3-iodoacetophenone

A series of novel 2,5,7-tricarbo-substituted indoles were prepared via sequential Sonogashira and Suzuki–Miyaura cross-coupling of 2-amino-5-bromo-3-iodoacetophenone with terminal acetylenes and aryl/styrylboronic acids followed by palladium chloride-medi

Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Interleukin-17 (IL-17) is a proinflammatory cytokine that plays a dominant role in inflammation, autoimmunity, and host defense. RORγt is a key transcription factor mediating T helper 17 (Th17) cell differentiation and IL-17 production, which is able to activate CD8+ T cells and elicit antitumor efficacy. A series of sulfonamide derivatives as novel RORγt inverse agonists were designed and synthesized. Using GSK2981278 (phase II) as a starting point, we engineered structural modifications that significantly improved the activity and pharmacokinetic profile. In animal studies, oral administration of compound d3 showed a robust and dose-dependent inhibition of the IL-17A cytokine expression in a mouse imiquimod-induced skin inflammation model. Docking analysis of the binding mode revealed that the compound d3 occupied the active pocket suitably. Thus, compound d3 was selected as a clinical compound for the treatment of Th17-driven autoimmune diseases.

One-Pot Synthesis of Spirocyclopenta[ a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramolecular Friedel-Crafts-type cyclization from propargyl alcohol-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments.

Novel 4-(1H-1,2,3-triazol-4-yl)methoxy)cinnolines as potent antibacterial agents: Synthesis and molecular docking study

A new series of cinnoline-1,2,3-triazole derivatives were designed and synthesized by adopting Cu(1) catalyzed regeoselective1,3-dipolar cycloaddition reaction of terminal alkyne and azide. The in vitro antibacterial activity of all these compounds revealed that compounds 9d, 10a, 10b, and 10c are more potent antibacterial agents. Among the series, compound 4-(3-(4-((cinnolin-4-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)morpholine (10b) exhibited the most potent antibacterial activity against all tested gram-positive and gram-negative bacterial strains. Furthermore, molecular docking studies were also performed to understand the binding interactions of the most active analogs 9d, 10a, 10b, and 10c with Elastase of Pseudomonas aeruginosa (PDB: 1U4G). The results indicated that these classes of compounds have potential antibacterial activity, especially the compound 10b may serve as a promising antibacterial lead compound that could be further optimized for the further development of antibacterial drugs.