292135-78-5 Usage
Description
Roflumilast N-Oxide, also known as the active metabolite of Roflumilast (R639700), is an off-white solid with significant pharmaceutical applications. It is derived from the parent compound Roflumilast, which is a phosphodiesterase-4 (PDE4) inhibitor. The N-Oxide form of the molecule exhibits enhanced properties and is utilized in various therapeutic areas.
Uses
Used in Pharmaceutical Industry:
Roflumilast N-Oxide is used as a therapeutic agent for the treatment of chronic obstructive pulmonary disease (COPD). It functions by inhibiting the PDE4 enzyme, which leads to an increase in cyclic AMP levels, reducing inflammation and improving lung function in patients with COPD.
Additionally, Roflumilast N-Oxide has shown potential in other application areas, such as:
Used in Anti-Inflammatory Applications:
Roflumilast N-Oxide is used as an anti-inflammatory agent due to its PDE4 inhibitory properties. It helps in reducing inflammation in various conditions, including autoimmune diseases and chronic inflammatory disorders.
Used in Neurodegenerative Disease Treatment:
Roflumilast N-Oxide is also being explored for its potential use in treating neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Its PDE4 inhibitory action may help in reducing neuroinflammation and protecting neurons from degeneration.
Used in Skin Care Industry:
In the skin care industry, Roflumilast N-Oxide is used as an ingredient in anti-aging and anti-inflammatory products. Its anti-inflammatory properties can help in reducing redness, swelling, and signs of aging, providing a more youthful and healthy appearance to the skin.
Check Digit Verification of cas no
The CAS Registry Mumber 292135-78-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,2,1,3 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 292135-78:
(8*2)+(7*9)+(6*2)+(5*1)+(4*3)+(3*5)+(2*7)+(1*8)=145
145 % 10 = 5
So 292135-78-5 is a valid CAS Registry Number.
292135-78-5Relevant articles and documents
Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes
Jeon, Jinwon,He, Yu-Tao,Shin, Sanghoon,Hong, Sungwoo
supporting information, p. 281 - 285 (2019/11/26)
The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process is initiated by the selective addition of a CF3 radical to the alkene to provide a nucleophilic alkyl radical intermediate, which enables an intramolecular endo addition exclusively to the ortho-position of the pyridinium salt. Both secondary and tertiary alkyl radicals are well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive molecules.
HYDRATED FORM OF ANTI-INFLAMMATORY ROFLUMILAST-N-OXIDE
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Page/Page column 17, (2012/01/14)
The present invention relates to new PDE4-inhibitors in a hydrated form, in particular of Roflumilast-N-oxide, methods of the manufacture thereof and pharmaceutical compositions comprising PDE4-inhibitors for parenteral administration.
