292873-75-7

Basic information

• Product Name: 3-cyclohexyl-5-{[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-(phenylimino)-1,3-thiazolidin-4-one
• Synonyms: 3-cyclohexyl-5-{[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-(phenylimino)-1,3-thiazolidin-4-one
• CAS NO: 292873-75-7
• Molecular Formula: C28H28FN3OS
• Molecular Weight: 473.6048232
• Mol File: 292873-75-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-cyclohexyl-5-{[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-(phenylimino)-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclohexyl-5-{[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-(phenylimino)-1,3-thiazolidin-4-one(292873-75-7)
• EPA Substance Registry System: 3-cyclohexyl-5-{[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene}-2-(phenylimino)-1,3-thiazolidin-4-one(292873-75-7)

Safety Data

• Hazardous Substances Data: 292873-75-7(Hazardous Substances Data)

Upstream product

• 54609-08-4 1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrole 
• 722-03-2 N-cyclohexyl-N'-phenylthiourea 
• 119673-50-6 1-(4-fluorophenyl)-2, 5-dimethyl-1H-pyrrole-3-carbaldehyde 
• 371-40-4 4-fluoroaniline 
• 110-13-4 2,5-hexanedione 

Relevant articles and documents

Discovery and optimisation studies of antimalarial phenotypic hits

There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were identified. Characterization of these compounds is discussed, along with approaches to optimise the physicochemical properties. The in vitro antimalarial activity of these compounds against P. falciparum K1 had EC50 values in the range of 0.09e29 mM, and generally good selectivity (typically >100-fold) compared to a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds.