29334-23-4

Basic information

• Product Name: Benzenemethanol, 2,4-dichloro-a-phenyl-
• CAS NO: 29334-23-4
• Molecular Formula: C13H10Cl2O
• Molecular Weight: 253.128
• Mol File: 29334-23-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2,4-dichloro-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2,4-dichloro-a-phenyl-(29334-23-4)
• EPA Substance Registry System: Benzenemethanol, 2,4-dichloro-a-phenyl-(29334-23-4)

Safety Data

• Hazardous Substances Data: 29334-23-4(Hazardous Substances Data)

Usage

Physical Appearance

white to off-white crystalline solid

Common uses

intermediate in pharmaceutical, agrochemical, and dye synthesis

Additional uses

antimicrobial, antiseptic agent; manufacturing of disinfectants, antiseptics, and preservatives

Health risks

should be handled and stored with care to avoid potential health hazards

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 98-80-6 phenylboronic acid 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 19811-05-3 2,4-dichlorobenzophenone 

Downstream Products

• 1042414-05-0 1-benzhydryl-3-[(2,4-dichlorophenyl)-phenyl-methoxy]-azetidine 
• 139029-71-3 2,4-dichloro-benzhydryl chloride 
• 75198-33-3 1-benzyl-2,4-dichlorobenzene 
• 1608462-19-6 2,4-dichloro-1-(1-phenylbut-3-enyl)benzene 
• 1426578-32-6 C₁₄H₁₂Cl₂O 
• 1313616-31-7 2,4-dichlorobenzhydryl-1H-1,2,4-triazole 
• 1313616-26-0 2,4-dichlorobenzhydryl-1H-imidazole 

Relevant articles and documents

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for tryptophan dioxygenase (TDO) and indoleamine 2,3-dioxygenase-2 (IDO2) which also have been implicated more recently in cancer, inflammation and immune control. Consequently the development of dual or pan inhibitors of these Trp catabolizing enzymes may represent a therapeutically important area of research. This is the first report to describe the development of dual and pan inhibitors of IDO1, TDO and IDO2.

Synthesis, antibacterial and antifungal activities of bifonazole derivatives

Two series of chlorinated benzhydryl imidazole and triazole derivatives were synthesized and tested in vitro against representative strains of potent pathogenic bacteria (Staphylococcus aureus CIP 4.83, Escherichia hirae CIP 5855, Pseudomonas aeruginosa CIP 82118, Escherichia coli CIP 53126) and fungi (Aspergillus niger IP 1431.83, Candida albicans IP 48.72, Candida krusei IP 208.52, Trichophython rubrum IP 1657.86). Most of these compounds were devoid of any antimicrobial activity, but several of them inhibited T. rubrum with MIC values in the range of 0.125 to 32 μg/mL, similar or superior to those of bifonazole and clotrimazole, used as standard controls. The replacement of the imidazole ring with a triazole moiety in these compounds led to derivatives with less antifungal activity. A preliminary SAR was undertaken on the effect of the number and the position of chlorine atoms on the distribution of negative charge on the surface of some compounds on antifungal activity. Copyright

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.