29874-83-7 Usage
Description
2-Chloro-4-phenylquinazoline is an organic compound with the molecular formula C15H9ClN2. It is a derivative of quinazoline, a fused heterocyclic compound consisting of a benzene ring fused to a pyrimidine ring. 2-CHLORO-4-PHENYLQUINAZOLINE is characterized by the presence of a chlorine atom at the 2nd position and a phenyl group at the 4th position of the quinazoline structure.
Uses
Used in Pharmaceutical Industry:
2-Chloro-4-phenylquinazoline is used as a pharmaceutical intermediate for the synthesis of MTH1 inhibitors, which are potential cancer eradicators. These inhibitors target the enzyme MTH1, which is overexpressed in various cancer cells, leading to the disruption of cancer cell metabolism and ultimately, the eradication of cancer cells.
Used in Chemical Research and Development:
2-Chloro-4-phenylquinazoline serves as an organic synthesis intermediate, primarily utilized in the laboratory research and development process. It is a key component in the synthesis of various complex organic molecules and pharmaceutical compounds, contributing to the advancement of chemical production processes and the discovery of new therapeutic agents.
Synthesis
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ° C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
Check Digit Verification of cas no
The CAS Registry Mumber 29874-83-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,8,7 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 29874-83:
(7*2)+(6*9)+(5*8)+(4*7)+(3*4)+(2*8)+(1*3)=167
167 % 10 = 7
So 29874-83-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H9ClN2/c15-14-16-12-9-5-4-8-11(12)13(17-14)10-6-2-1-3-7-10/h1-9H
29874-83-7Relevant articles and documents
COMPOUND FOR AN ORGANIC ELECTRIC ELEMENT, AN ORGANIC ELECTRIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
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Paragraph 0082-0083, (2021/06/11)
The present invention provides the compound represented by Formula 1, an organic electric element comprising a first electrode, a second electrode, and an organic material layer formed between the first electrode and the second electrode, and electronic d
Aromatic compound and organoelectroluminescent device comprising the compound
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Paragraph 0819-0824, (2021/08/31)
The present invention relates to an aromatic compound and an organic electroluminescent device including the same. The aromatic compound is represented by chemical formula 1, and the organic electroluminescent device is excellent in driving voltage, luminous efficiency and lifetime characteristics.
Novel organic compounds for organic light-emitting diode and organic light-emitting diode including the same
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Paragraph 0354; 0360-0364, (2020/08/29)
The present invention relates to an organic light emitting compound represented by formula A and an organic light emitting diode including the same. Substituents A1 to A4, R1 to R17, X, Y, a, b, m, n, p, L1, and L2 are identical to as defined in the detailed description.
